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Hematology, Oncology, and Cellular Therapy

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Research

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Leading the fight against childhood cancer: Bringing research from the laboratory to the bedside

At CHAM, we are dedicated to improving outcomes for children with cancer and blood disorders. Our cross-disciplinary research model brings together outstanding physicians with internationally-recognized scientists at Albert Einstein College of Medicine to develop our own innovative therapeutics and treatment strategies. We confront highly aggressive forms of pediatric cancer and blood disorders with an equally aggressive push toward advancing the field.

Providing access to clinical trials worldwide

The Pediatric Hematology, Oncology, and Cellular Therapy team at CHAM is at the forefront of clinical research and development in the field of childhood cancer and blood disorders, actively involved in defining the next generation of treatment. To do this, our physician-scientists are developing new treatments in their research labs and we work closely with other leading children’s hospitals around the world to bring the latest and most promising treatment options to our patients. Clinical trials at CHAM allow our patients to be among the first to try pioneering treatment agents and concepts.

CHAM is an active member of many national and international consortia of pediatric cancer centers dedicated to advancing treatment for children with cancer by combining global resources and expertise for clinical trials. We participate in studies through the Children’s Oncology Group (COG) and National Institutes of Health (NIH), Dana-Farber Cancer Institute, the National Pediatric Cancer Foundation, as well as industry-sponsored and NIH-supported investigator-initiated clinical trials.

In all areas of research, the CHAM Hematology, Oncology, and Cellular Therapy team is a key player in the ultimate fight — to one day entirely eradicate childhood cancer and blood disorders.

Below is a listing of current clinical trials in Childhood Cancers and Blood Disorders

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionChemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma - Click here for more informationIRB# 08-03-057
Disease/ConditionBrain Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionChemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors - Click here for more informationIRB# 12-08-281
Disease/ConditionBrain Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Biological Samples From Patients With Ewing Sarcoma - Click here for more informationIRB# 08-09-335
Disease/ConditionBone Cancer
Principal InvestigatorPeter Cole, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma - Click here for more informationIRB# 08-09-336E
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Tissue From Young Patients With Cancer - Click here for more informationABTR04B1
Disease/ConditionCancer and Genetics
Principal InvestigatorPeter Cole, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma - Click here for more informationIRB# 1199905158
Disease/ConditionSoft Tissue Sarcoma/Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionDenosumab in Treating Patients With Recurrent or Refractory Osteosarcoma - Click here for more informationIRB# AOST1321
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionDinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma - Click here for more informationIRB# AOST1421
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionGlembatumumab Vedotin in Treating Patients With Recurrent or Refractory Osteosarcoma - Click here for more informationIRB# AOST1521
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionInternational Registry for Severe Chronic Neutropenia - Click here for more informationIRB# 03-01-015E
Disease/ConditionBlood Disorders and Diseases
Principal InvestigatorKerry Morrone, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionIntravenous Gammaglobulin for Sickle Cell Pain Crises - Click here for more informationIRB # 09-06-172
Disease/ConditionBlood Disorders and Diseases
Anesthesia and Pain Management
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland
(718) 741-2401
Email Contact
Trial DescriptionMatched Targeted Therapy (MTT) Recommendation for Patients with Recurrent, Refractory, or High Risk Leukemias - Click here for more information2016-5971
Disease/ConditionPediatric Hematology/Oncology
Leukemia
Neoplasms
Blood Disorders and Diseases
Cancer
Principal InvestigatorLisa Gennarini, MD
Contact Annette Pedro

Email Contact
Trial DescriptionMetformin in Children With Relapsed or Refractory Solid Tumors - Click here for more informationIRB# 12-05-190
Disease/ConditionSolid Tumor
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionMulticenter Cohort Study To Evaluate Outcomes After Receipt of Targeted Therapy Matched to an Individualized Cancer Therapy (iCat) Recommendations in Children and Young Adults With Solid Tumors: The iCat2, GAIN Consortium Study - Click here for more information2016-7341
Disease/ConditionCancer
Hematologic Diseases
Pediatric Hematology/Oncology
Solid Tumor
Principal InvestigatorDaniel Weiser, MD
Contact Annette Pedro

Email Contact
Trial DescriptionProfiling Actionable Genetic Alterations in Pediatric Tumors: The Children's Hospital at Montefiore Protocol for Screening Pediatric Tumors to Define Genetic Alterations IRB# 2014-3436
Disease/ConditionCancer and Genetics
Principal InvestigatorAdam Levy, MD
Contact Janeta Ivanova
(718) 741-2356
Email Contact
Trial DescriptionProject: Every Child for Younger Patients With Cancer - Click here for more informationIRB# 2016-5989
Disease/ConditionCancer and Genetics
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionRadiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery (PAZNTIS) - Click here for more informationIRB# 2015-4866
Disease/ConditionSoft Tissue Sarcoma/Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2338
Email Contact
Trial DescriptionRisk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer - Click here for more informationIRB# 10-04-087
Disease/ConditionLiver Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionStudy of Kidney Tumors in Young Patients - Click here for more informationIRB# 08-05-181E
Disease/ConditionKidney Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionStudy to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload - Click here for more informationIRB# 15-02-284
Disease/ConditionBlood Disorders and Diseases
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland
(718) 741-2401
Email Contact
View all Clinical Trials