Cancers and Blood Disorders – Research | The Children's Hospital at Montefiore

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Research

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Leading the fight against childhood cancer: Bringing research from the laboratory to the bedside

At CHAM, we are dedicated to improving outcomes for children with cancer and blood disorders. Our cross-disciplinary research model brings together outstanding physicians with internationally-recognized scientists at Albert Einstein College of Medicine to develop our own innovative therapeutics and treatment strategies. We confront highly aggressive forms of pediatric cancer and blood disorders with an equally aggressive push toward advancing the field.

Providing access to clinical trials worldwide

The Pediatric Hematology, Oncology, and Cellular Therapy team at CHAM is at the forefront of clinical research and development in the field of childhood cancer and blood disorders, actively involved in defining the next generation of treatment. To do this, our physician-scientists are developing new treatments in their research labs and we work closely with other leading children’s hospitals around the world to bring the latest and most promising treatment options to our patients. Clinical trials at CHAM allow our patients to be among the first to try pioneering treatment agents and concepts.

CHAM is an active member of many national and international consortia of pediatric cancer centers dedicated to advancing treatment for children with cancer by combining global resources and expertise for clinical trials. We participate in studies through the Children’s Oncology Group (COG) and National Institutes of Health (NIH), Dana-Farber Cancer Institute, the National Pediatric Cancer Foundation, as well as industry-sponsored and NIH-supported investigator-initiated clinical trials.

In all areas of research, the CHAM Hematology, Oncology, and Cellular Therapy team is a key player in the ultimate fight — to one day entirely eradicate childhood cancer and blood disorders.

Below is a listing of current clinical trials in Childhood Cancers and Blood Disorders

Active Clinical Trials

Trial DescriptionA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications - Click here for more information2014-4194

Disease/ConditionAnemia
Hematologic Diseases
Immune System Diseases
Leukemia
Lymphoma
Lymphoproliferative Disorders
Neoplasms
Non-Hodgkins Lymphoma
Oncology (Medical/Hematologic)
Pediatric Hematology/Oncology
Blood Disorders and Diseases

Principal InvestigatorDavid Loeb, MD

Contact Christopher Hall

Email Contact

Trial DescriptionA Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units Manufactured by the National Cord Blood Program and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients - Click here for more information2015-5071

Disease/ConditionBlood and Bone Marrow Cancer
Blood Disorders and Diseases

Principal InvestigatorDavid Loeb, MD

Contact Christopher Hall

Email Contact

Trial DescriptionA Phase 3, Randomized, Open-Label, Multicenter Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD) - Click here for more information18-10-59-01

Disease/ConditionHematologic Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Metabolic Diseases
Nephrology
Urologic Diseases
Pediatrics

Principal InvestigatorAnna Zolotnitskaya, MD

Contact Patricia Flynn

Email Contact

Trial DescriptionA Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide and All-Trans Retinoic Acid - Click here for more information2018-9045

Disease/ConditionLeukemia
Oncology (Medical/Hematologic)
Pancreatic Cancer
Pediatric Hematology/Oncology
Neoplasms

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown

Email Contact

Trial DescriptionA Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) - Click here for more information2016-6694

Disease/ConditionAnemia
Blood Disorders and Diseases
Sickle Cell
Pediatrics
Genetic Disorders
Hematologic Diseases

Principal InvestigatorCaterina Minniti, MD

Contact Andrew Crouch

Email Contact

Trial DescriptionA Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease - Click here for more information18-06-66Q-01

Disease/ConditionCardiology
Oncology (Medical/Hematologic)
Urogenital Neoplasms
Urologic Oncology (Med Onc)
Prostate Cancer

Principal InvestigatorBenjamin Gartrell, MD

Contact Gina Aracena

Email Contact

Trial DescriptionA Trial of Endocrine Response in Women With Invasive Lobular Breast Cancer - Click here for more information2016-7457

Disease/ConditionBreast Cancer
Neoplasms
Oncology (Medical/Hematologic)
Women`s Health

Principal InvestigatorJoseph Sparano, MD

Contact Amanda Erakky

Email Contact

Trial DescriptionBrentuximab Vedotin and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Hodgkin Lymphoma - Click here for more information2015-4877

Disease/ConditionLymphoproliferative Disorders
Neoplasms
Pediatric Hematology/Oncology
Blood and Bone Marrow Cancer
Immune System Diseases
Lymphatic and Spleen Diseases
Lymphoma

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown

Email Contact

Trial DescriptionCOG-ANBL00B1 Neuroblastoma Biology Studies - Click here for more information1200011361

Disease/ConditionMedical and Hematologic Oncology
Neuroblastoma
Neoplasms

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown

Email Contact

Trial DescriptionCombination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations - Click here for more information2015-4852

Disease/ConditionBlood and Bone Marrow Cancer
Immune System Diseases
Leukemia
Lymphatic and Spleen Diseases
Lymphoma
Lymphoproliferative Disorders
Neoplasms
Pediatric Hematology/Oncology

Principal InvestigatorLisa Gennarini, MD

Contact Annette Pedro

Email Contact

Trial DescriptionHydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial - Click here for more information2017-8570

Disease/ConditionAnemia
Hematologic Diseases
Pediatric Hematology/Oncology
Pediatrics
Genetic Disorders

Principal InvestigatorDeepa Manwani, MD

Contact Karen Ireland

Email Contact

Trial DescriptionInternational Registry for Severe Chronic Neutropenia - Click here for more informationIRB# 03-01-015E

Disease/ConditionBlood Disorders and Diseases

Principal InvestigatorKerry Morrone, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionIntravenous Gammaglobulin for Sickle Cell Pain Crises - Click here for more informationIRB # 09-06-172

Disease/ConditionBlood Disorders and Diseases
Anesthesia and Pain Management

Principal InvestigatorDeepa Manwani, MD

Contact Karen Ireland
(718) 741-2401
Email Contact

Trial DescriptionMatched Targeted Therapy (MTT) Recommendation for Patients with Recurrent, Refractory, or High Risk Leukemias - Click here for more information2016-5971

Disease/ConditionPediatric Hematology/Oncology
Leukemia
Neoplasms
Blood Disorders and Diseases
Cancer

Principal InvestigatorLisa Gennarini, MD

Contact Annette Pedro

Email Contact

Trial DescriptionMetformin in Children With Relapsed or Refractory Solid Tumors - Click here for more information12-05-190

Disease/ConditionSolid Tumor

Principal InvestigatorDaniel Weiser, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionMulticenter Cohort Study To Evaluate Outcomes After Receipt of Targeted Therapy Matched to an Individualized Cancer Therapy (iCat) Recommendations in Children and Young Adults With Solid Tumors: The iCat2, GAIN Consortium Study - Click here for more information2016-7341

Disease/ConditionCancer
Hematologic Diseases
Pediatric Hematology/Oncology
Solid Tumor

Principal InvestigatorDaniel Weiser, MD

Contact Annette Pedro

Email Contact

Trial DescriptionMulticenter, Open Label, Phase 3 Study of Tabelecleucel for Solid Organ Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE) - Click here for more information16-10-296-01

Disease/ConditionEpstein-Barr Virus (EBV)
Lymphoproliferative Disorders
Pediatric Hematology/Oncology
Pediatrics
Solid Organ Transplant (SOT) Complications
Immune System Diseases

Principal InvestigatorDavid Loeb, MD

Contact Elodie Benard

Email Contact

Trial DescriptionMulticenter, Open-Label, Phase 3 Study of Tabelecleucel for Allogeneic Hematopoietic Cell Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab (MATCH Study) - Click here for more information16-10-211-01

Disease/ConditionEpstein-Barr Virus (EBV)
Immune System Diseases
Lymphatic and Spleen Diseases
Lymphoma
Lymphoproliferative Disorders
Pediatric Hematology/Oncology
Cancer

Principal InvestigatorDavid Loeb, MD

Contact Elodie Benard

Email Contact

Trial DescriptionNeuropsychological and Behavioral Testing in Younger Patients With Cancer - Click here for more information09-04-137E

Disease/ConditionSupportive Cancer Care

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionOpen-label, Phase I/II Study to Evaluate Pharmacokinetics, Pharmacodynamics, Safety, and Anticancer Activity of Avelumab in Pediatric Subjects From Birth to Less Than 18 Years of Age With Refractory or Relapsed Solid Tumors and Lymphoma - Click here for more information17-10-398Q-01

Disease/ConditionImmune System Diseases
Lymphatic and Spleen Diseases
Lymphoma
Lymphoproliferative Disorders
Neoplasms
Pediatric Hematology/Oncology
Solid Tumor

Principal InvestigatorDavid Loeb, MD

Contact David Loeb, MD

Email Contact

Trial DescriptionPersonalized Medicine: Pediatric Total Cancer Care™ Protocol 2013-2690

Disease/ConditionSupportive Cancer Care

Principal InvestigatorDaniel Weiser, MD

Contact Annette Pedro
718-741-2356
Email Contact

Trial DescriptionProject: Every Child for Younger Patients With Cancer - Click here for more information2016-5989

Disease/ConditionCancer and Genetics

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionProphylactic Antibiotic Regimens in Tumor Surgery (PARITY): A Multi-Center International Randomized Controlled Trial Comparing Alternative Antibiotic Regimens in Patients Undergoing Tumor Resections With Endoprosthetic Replacements - Click here for more information2014-4077

Disease/ConditionBone Cancer
Cancer
Infectious Diseases
Musculoskeletal Diseases
Neoplasms
Surgery

Principal InvestigatorDavid Geller, MD

Contact David Geller, MD

Email Contact

Trial DescriptionProtocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries - Click here for more information08-05-156E

Disease/ConditionNeoplasms
Oncology (Medical/Hematologic)
Pediatric Hematology/Oncology
Blood and Bone Marrow Cancer
Blood Disorders and Diseases
Hematologic Diseases

Principal InvestigatorIra Braunschweig, MD

Contact Novneet Sandhu

Email Contact

Trial DescriptionProtocol for a Research Sample Repository and for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies, and Marrow Toxic Injuries - Click here for more information2015-5698

Disease/ConditionHematologic Diseases
Neoplasms
Pediatric Hematology/Oncology
Pediatrics
Oncology (Medical/Hematologic)

Principal InvestigatorDavid Loeb, MD

Contact Marissa Green

Email Contact

Trial DescriptionProtocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation - Click here for more information08-05-155E

Disease/ConditionAutoimmune Diseases
Blood and Bone Marrow Cancer
Blood Disorders and Diseases

Principal InvestigatorIra Braunschweig, MD

Contact Novneet Sandhu
(718) 405-8446
Email Contact

Trial DescriptionRadiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery (PAZNTIS) - Click here for more information2015-4866

Disease/ConditionSoft Tissue Sarcoma/Cancer

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown
(718) 741-2338
Email Contact

Trial DescriptionRisk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia - Click here for more information12-01-021

Disease/ConditionBlood and Bone Marrow Cancer

Principal InvestigatorPeter Cole, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionRisk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL) - Click here for more information2015-4876

Disease/ConditionEpstein-Barr Virus (EBV)
Leukemia
Lymphoma
Lymphoproliferative Disorders
Oncology (Medical/Hematologic)
Neoplasms
Non-Hodgkins Lymphoma

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown

Email Contact

Trial DescriptionSafety Study of Gene Modified Donor T-cells Following TCR Alpha Beta Depleted Stem Cell Transplant - Click here for more informationIRB# 15-11-347

Disease/ConditionBlood and Bone Marrow Cancer

Principal InvestigatorKris Mahadeo, MD

Contact Ruth Santizo
(718) 741-2287
Email Contact

Trial DescriptionStudy of Allogeneic EBV-CTLs in EBV-Associated Viremia or Malignancies - Click here for more information16-10-116-01

Disease/ConditionHematologic Diseases
Pediatrics

Principal InvestigatorDavid Loeb, MD

Contact Elodie Benard

Email Contact

Trial DescriptionStudy of Kidney Tumors in Young Patients - Click here for more information08-05-181E

Disease/ConditionKidney Cancer

Principal InvestigatorLisa Gennarini, MD

Contact Joyce Brown
(718) 741-2356
Email Contact

Trial DescriptionThe Chimerix CMX001 Registry - Click here for more informationIRB# 14-06-233-01

Disease/ConditionBlood and Bone Marrow Cancer

Principal InvestigatorOlga Derman, MD

Contact Karen Fehn
(718) 405-8446
Email Contact

Trial DescriptionTreatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents - Click here for more information2017-8449

Disease/ConditionLeukemia
Lymphatic and Spleen Diseases
Neoplasms
Pediatric Hematology/Oncology
Lymphoproliferative Disorders

Principal InvestigatorLisa Gennarini, MD

Contact Lisa Gennarini, MD

Email Contact

View all Clinical Trials