Pediatric Infectious Disease Division Research Highlights 2023-2024
MANUSCRIPTS: (Graduate students, residents, fellows, mentees are in italics and ID faculty are bolded)
- Kuraoka, M., Burn Achner, C., Windsor I.W., Mahant, A.M., Garforth, Sc., Kong, S.L., Achkar, J.M., Almo, S.C., Kelsoe, G., and Herold, B.C. A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice. JCI 2023 Feb 1;133(3):e161968 PMC9888390
- Estrada, F., Mahant, A.M., Guerguis, S., Sy, S., Lu, C., Reznik, S.E., and Herold, B.C. Prolonged Preterm Rupture of Membranes Associated with Neonatal Disseminated Herpes Simplex Virus Type 1 at Birth: Is there a role for preemptive test and treat strategies in high-risk populations? JPIDS, 2023 March 31 PMID 37001048
- Lu, J.Y., Wilson, J., Hou, W., Fleysher, R., Herold, B.C., Herold, K.C., Duong, T.Q. Incidence of new-onset in-hospital and persistent diabetes in COVID-19 patients: comparison with influenza. eBioMedicine 2023; 90: 104487 PMID 36857969
- Pierce, C.A., Loh, L.N., Steach, H.R., Cheshenko, N.C., Preston-Hurlburt, P., Zhang, F., Stransky, S., Kravets, L., Sidoli, S., Philbrick, W.M., Nassar, M.N., Krishnaswamy, S., Herold, K.C.*, Herold, B.C.* (*contributed equally). HSV-2 triggers upregulation of Malat1 in CD4+ T cells and promotes HIV latency reversal. JCI, 2023, June 1; 133(11):e16531 PMC10232005.
- Demirhan, S. Munoz, F.M., Valencia-Deray, K., Bocchini, C., Danziger-Isakov, L., Blum, S., Sharma, T.S., Sherman, G., Boguniewicz, J., Bacon, S., Ardura, M.I., Maron, G.M., Ferrolino, J., Foca, M* and Herold, B.C.* (*contributed equally). Body surface area compared to body weight dosing of valganciclovir is associated with increased toxicity in pediatric solid organ transplantation recipients. American Journal of Transplantation, 2023 Dec;23(12):1961-1971. PMID: 37499799
- Mahant, A.M., Gromisch, M.S., Kravets, L., Aschner, C.B., and Herold, B.C. Greater durability and protection against herpes simplex viral disease following immunization of mice with single-cycle DgD-2 compared to an adjuvanted glycoprotein D protein vaccine. Vaccines, 2023 Ayg14; 11(18): 1362.
- Mahant, A.M, Estrada Trejo, F., Aguilan, J.T., Sidoli, S., Permar, S.R., and Herold, B.C. Antigenic target, clycans, affinity for and placental expression of Fc receptors modulate HSV IgG transfer. iScience, 2023 Aug. 15;26(9):107648 PMID: 37670782
- Menezes ME, Silver EJ, Goldstein DY, Fox AS, Collins-Ogle, MD, Coupey SM. Prevalence and Factors Associated with Mycoplasma genitalium Infection in At-risk Female Adolescents in Bronx County, New York. Sex Transm Dis. 2023 Oct1;50(10):635-41. PMID: 37255234
- Demirhan S, Anosike BI. Bugs under the skin: Traveller's foot. J Paediatr Child Health. 2023 Feb 11. doi: 10.1111/jpc.16373. Epub ahead of print. PMID: 36772963.
- Tarun S, Makadia L, Demirhan S, Shah SS, Foca MD, Bacha EA, Thai L, Bansal N, Pagan CA, Barry OM. Surgical and medical management of purulent bacterial oericarditis with pericardial mass in a young child. JACC Case Rep. 2023 May 5;15:101834. doi: 10.1016/j.jaccas.2023.101834. PMID: 37283835
- Lee P, Nemati K, Silver E, Cacace J, Goldman DL. Risk factors for recurrent Clostridioides difficile infection in Children. Hosp Pediatr. 2023 Nov 1;13(11):1010-1017. PMID 37877183
- Demirhan, S., Escobar Lee, K., Herold, B.C. Visual hallucinations and headache in a returining adolescent traveler. Clin Pediatric 2024 PMID: 38787296.
- Demirhan, S., Goldman, D.L., and Herold, B.C. Differences in the clinical manifestations and host immune responses to SARS-CoV-2 variants in children compared to adults. Jour Clin Med 2023 Dec.26 ;13(1):128. doi: 10.3390/jcm13010128.
- Murphy, K, Gromisch, M., Srinivasan, S., Wang, T., Wood, L, Proll, S., Liu, C. Fiedler, T., Valint, D.J., Fredricks, D., Keller, M.J., and Herold, B.C. IgA coating of vaginal bacteria is reduced in the setting of bacterial vaginosis (BV) and preferentially targets BV-associated species. Infection and Immunity, 2024 PMID:38099624
- Mauck, C., Thurman, A., Jensen, J.T., Schreiber, C.A., Baker, J., Hou, M.Y., Chavoustie, S. Dart, C., Wu, H., Ravel, J. Gajer, P. Herold, B.C., Jacot, T., Zack, N. Hatheway, J., and Friend, D. Safety testing of Ovaprene: an investigational non-hormonal monthly vaginal contraceptive. Contraception, 2024 PMID: 38552818
- Murphy, K., Shi, Q, Hoover D., Adimora, A., Alcaide, M., Brockmann, S., Duggal, P., French A., Michel, K., Dione-Odom, J., Sheth, A., Keller, M., Herold, B.C., Anastos, K., and Aouizerat, B. Genetic predictors for bacterial vaginosis in women living with and at risk for HIV infection. Am J Repro Imm, 2024 PMID: 38720636
- Ferretti, C.J., Cook, B., Mahant, A.M., Chu, P, Zhao, Y., Taylor, B., Herold, B.C. and Hollander, E. Cognitive Inflexibility, and Immunome Biomarkers in Children with Autism Spectrum Disorder (ASD). Neuroscience Applied, 2024, in press.
- Foca, M., Demirhan, S., Munoz, F.M., Valencia Deray, K.G, Bocchini, C.E., Sharma, T.S., Sherman, G., Muller, W.J., Heald Sargent, T. Danziger-Isakov, L. Blum, S., Boguniewicz, J., Bacon, S., Joseph, T., Smith, J., Ardura, M.I., Su, Y., Maron, G.M., Ferrolino, J. and Herold, B.C. Multicenter analysis of valganciclovir prophylaxis in pediatric solid organ transplantation recipients. Open Forum Infectious Diseases, 2024 Jul 1;11(7):ofae353. doi: 10.1093 PMID: 38979014
- Feldman AG, Beaty BL, Ferrolino JA, Maron G, Foca, M, et al. Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients. JAMA Netw Open. 2023 PMID: 37824141.
- Demirhan S, Foca M. A 9-Month-old Infant with Non-healing Oral Ulcers. Pediatr Infect Dis J. 2023 PMID: 37729668.
- Demirhan S, King Z, Sohail SS, Merzel D, Lamson DM, Palezac L, Tanner TI, Loeb DM, Foca M. Human Adenovirus B3 Associated Colitis and Hemophagocytic Lymphohistiocytosis in 9-Year-old Previously Healthy Girl. Pediatr Infect Dis J. 2024 PMID: 38502897.
- Tang KM, Lee P, Anosike BI, Asas K, Cassel-Choudhury G, Devi T, Gennarini L, Raizner A, Rhim HJH, Savva J, Shah D, Philips K. Decreasing Prescribing Errors in Antimicrobial Stewardship Program-Restricted Medications. Hosp Pediatr. 2024 Apr 1;14(4):281-290. doi: 10.1542/hpeds.2023-007548. PMID: 38482585.
- Aparicio C, Willis ZI, Nakamura MM, Wolf J, Little C, Maron GM, Sue PK, Anosike BI, Miller C, Bio LL, Singh P, James SH, Oliveira CR; PIDS Pediatric COVID-19 Therapies Task Force. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis. J Pediatric Infect Dis Soc. 2024 May 23:piae052. doi: 10.1093/jpids/piae052. Epub ahead of print. PMID: 38780125.
- Willis ZI, Oliveira CR, Abzug MJ, Anosike BI, Ardura MI, Bio LL, Boguniewicz J, Chiotos K, Downes K, Grapentine SP, Hersh AL, Heston SM, Hijano DR, Huskins WC, James SH, Jones S, Lockowitz CR, Lloyd EC, MacBrayne C, Maron GM, Hayes McDonough M, Miller CM, Morton TH, Olivero RM, Orscheln RC, Schwenk HT, Singh P, Soma VL, Sue PK, Vora SB, Nakamura MM, Wolf J. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. J Pediatric Infect Dis Soc. 2024 Mar 19;13(3):159-185. doi: 10.1093/jpids/piad116. PMID: 38339996.
CHAPTERS
- Goldman DL. Mycoplasma Infections Goldman-Cecil Medicine (27th Edition). Elsevier (2023).
- Goldman DL. Cryptococcosis in Nelson Textbook of Pediatrics (22nd Edition). Elsevier (2024)
- Goldman DL and Perfect JR. Cryptococcosis in Feigin and Cherry's Textbook of Pediatric Infectious Diseases (9th Edition) Elsevier (2024 in press)
- Collins-Ogle, M., Regelmann, M., Transgender Youth in The Five Minute Pediatric Consult. (9th Edition) Volters Kluwer (2024 in press)
ACTIVE GRANTS AND CONTRACTS:
- Michelle Collins-Ogle: Gilead Lenacapavir PURPOSE 2 study (Site PI)
- Michelle Collins-Ogle: NIH “Expanding PrEP n Communities of Color” (EPICC) (Site PI)
- Julia Piwoz: New York State DOH Neonatal CMV Screening (Site PI)
- Marc Foca: EBV T cell Immunity as a Biomarker for PTLD Risk; Viracor-Eurofins (PI)
- Marc Foca: NIH R01AI159684: Multicenter evaluation of the threat of established and emerging respiratory viral infections in pediatric transplant recipients (MPI: Steinbach, Tuomanen, Englund and Herold). (Role: SITE PI)
- Brenda (IJ) Anosike: AAMC Center for Health Justice Building Trust and Confidence Through Partnerships Grant (Role: Co-PI)
- Betsy Herold: NIH R01AI159684: Multicenter evaluation of the threat of established and emerging respiratory viral infections in pediatric transplant recipients (Role: MPI).
- Betsy Herold: R01AI177673 Optimizing the generation of mAbs for prevention and treatment of HSV disease (Role: PI)
- Betsy Herold: 2ER01AI134367: Mechanisms underlying the HIV-HSV-2 Syndemic (Role: PI)
- Betsy Herold: R01HD098977: Impact of the vaginal microbiome on HIV PrEP (Role: PI)
- Betsy Herold: P30 AI124414: Einstein/Rockefeller/CUNY CFAR (Associate Director)
- Betsy Herold: UM1 AI068613. HIV Prevention Trials Network (Co-I, Biomedical Sciences Working Group, Lab Core)
AWARDS:
- Michelle Collins-Ogle (Faculty): IDSA Society Citation Award
- Salih Demirhan (Fellow). ID Week Trainee Abstract Travel Award
- Salih Demirhan (Fellow): IDSNY Fellow Abstract Award
- Salih Demirhan (Fellow): American Transplant Congress: Abstract and Travel Award
- Betsy Herold (Faculty). Ruth L. Gottesman Award for Scientific Advancement, Einstein College of Medicine
- Kiriam Escobar Lee (Fellow) ESCMID Travel Grant