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Nephrology

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Research

Our basic, clinical and translational research is aimed at identifying the major problems affecting children from birth throughout the life-course and into transition to adult care including: 

  • Disorders of abnormal kidney and genitourinary tract development
  • Genetics of inherited kidney abnormalities and predisposition to chronic kidney injury
  • Acquired kidney conditions including the nephrotic syndrome of childhood, immune-mediated disorders, high blood pressure and progressive kidney failure in the transplanted organ

We participate in the NIH-funded collaborative clinical trials to better understand chronic kidney disease, its prevention, and more effective treatment in children including:

Standardized Care to Improve Outcomes in Pediatric End-Stage Renal Disease (SCOPE)

Our pediatric dialysis center is an active member of the SCOPE collaborative, a multicenter performance improvement workgroup focused on reducing the rates of exit-site infections and peritonitis for children receiving chronic peritoneal dialysis. Through this network, CHAM patients have seen a 27 percent reduction in peritonitis rates already.

Understanding Focal Glomerulosclerosis

We are examining the role of Par1a/b in establishing and maintaining podocyte structure and de­fining polarity protein expression in human nephrotic syndrome and glomerulosclerosis. The team is hoping to identify new targets for therapeutic intervention and biomarkers for progressive kidney disease, and anticipates these discoveries will allow for early detection and early intervention as well as better treatments for focal glomerulosclerosis. In addition, we are involved in a collaboration examining the important risk cardiovascular alleles APOL 1 and 2 in African Americans born prematurely.

Better Diagnosis and Tailored Treatments for Lupus Nephritis

We are studying the role of microRNAs in the development and progression of lupus nephritis, their detection in human urine samples, and their role as biomarkers of active disease. We hope to find biomarkers that can both diagnose and measure disease, which may lead to tailored treatments rather than the current use of immunosuppressant drugs that target the whole kidney and can cause unwanted side effects.

The Nephrotic Syndrome Rare Disease Clinical Research Network and Cure Glomerulonephropathy

A collaboration conducting clinical and translational research in the major causes of glomerular diseases in children and adults.

The Chronic Kidney Disease in Children Cohort

A collaboration aimed at determining the risk factors for progressive kidney failure in infants and children and its effects on neurocognition, cardiovascular disease and growth and development.

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Phase 3, Randomized, Open-Label, Multicenter Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD) - Click here for more information18-10-59-01
Disease/ConditionHematologic Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Metabolic Diseases
Nephrology
Urologic Diseases
Pediatrics
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionEfficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker - Click here for more information2017-8362
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Nephrology
Pediatrics
Urologic Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionNephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network (NEPTUNE) - Click here for more information09-06-182
Disease/ConditionGeriatrics
Kidney Diseases (incl Chronic Kidney Disease)
Nephrotic Syndrome
Pediatrics
Urologic Diseases
Immune System Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionNorth American Pediatric Renal Trials and Collaborative Studies IRB# 02-06-151E
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Principal InvestigatorMarcela Del Rio, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionOutcomes of Neonatal Acute Kidney Injury In Premature Infants - Click here for more information2013-2900
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Principal InvestigatorMamta Fuloria, MD
Contact Mamta Fuloria, MD
(718) 904-4105
Email Contact
Trial DescriptionPharmacodynamic & Safety of Patiromer in Children & Adolescents (2-<18 Yrs) With Chronic Kidney Disease and Hyperkalemia (EMERALD) - Click here for more information16-10-391-01
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Anna Zolotnitskaya, MD

Email Contact
Trial DescriptionPhase III Multicenter Open-label Randomized Clinical Trial Comparing Everolimus and Low Dose Tacrolimus to Tacrolimus and Mycophenolate Mofetil at 6 mo Post-Transplant to Prevent Long-term Complications After Pediatric Heart Transplantation - Click here for more information2017-8626
Disease/ConditionHeart and Vascular Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Pediatrics
Urologic Diseases
Cardiovascular and Thoracic Surgery
Principal InvestigatorJacqueline Lamour, MD
Contact Helen Alexander

Email Contact
View all Clinical Trials