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General Pediatrics (Academic General Pediatrics)

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Research 

We are dedicated to providing the highest quality clinical care to our patients, while also conducting cutting-edge biomedical research targeting diseases that affect infants, children and adolescents.

Our team is making significant breakthroughs in understanding the molecular and cellular mechanisms of diseases. These discoveries are enabling us to pioneer innovative therapies for our pediatric patients. It’s all in the pursuit of our ultimate mission: To further our understanding of the disease process in order to improve the treatment of and quality of life for all of our patients.

We are currently focused on research to:

  • Find a better way to transition youth with special healthcare needs to the adult medical world: Youth with chronic medical, emotional and developmental problems deserve continuous coordinated medical care as they age out of their pediatric practices. Research to determine how physicians assist families and their teens in their journey to adulthood is being evaluated in order to improve the process.
  • Increase physical activity in order to improve asthma management in children: We are studying ways to eliminate barriers to physical activity that inner-city children with asthma face. Our school- and community-based research has determined that students with asthma may withdraw from physical activity for a number of reasons. These include: inappropriate school asthma management, poor asthma control, lack of accessible medication and feelings of embarrassment when using asthma medication in public. In partnership with community and school representatives, our team has developed a school-based program to address these barriers and thus improve asthma management both at home and at school.
  • Create a healthier, pest-free home environment for children with asthma: In another study conducted in collaboration with the New York City Department of Health, along with several insurance companies, families of children with persistent asthma are receiving an integrated pest management home visit to reduce pests (cockroaches and mice) that can exacerbate a child’s asthma. The question we are trying to answer with this research study is: “If we reduce pests in the home of a child with asthma, will that child have fewer days with symptoms, fewer trips to the emergency room or hospital, and fewer days missed of school?”
  • Detecting and rectifying poorly controlled asthma through better understanding of contributing environmental factors: Research and advocacy efforts are aimed at addressing ways to improve the detection and treatment of poorly controlled asthma and at increasing the recognition and remediation of environmental factors that contribute to asthma symptoms.
  • Improve coordination of care for children and families who have experienced trauma contributing to chronic behavioral health issues: Trauma, also known as adverse childhood experiences (ACEs), affects children and families in many ways, and can result in toxic levels of stress that may negatively impact a child's developing brain and their overall physical health. We are studying the rates and types of ACEs in children presenting with behavioral problems, such as attention deficit hyperactivity disorder (ADHD). Our hope is to discover ways to maximize coordination between health and social services for this population. The findings from our research will be used to strengthen partnerships between healthcare providers and local community organizations, in order to facilitate care coordination via novel approaches that are sensitive and responsive to the unique needs of children and families that have experienced trauma.

 

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Long-Term, Open-Label Follow-up Study of Tofacitinib for Treatment of Juvenile Idiopathic Arthritis (JIA) - Click here for more information15-10-199-01
Disease/ConditionArthritis
Autoimmune Diseases
Musculoskeletal Diseases
Pediatrics
Rheumatic Diseases
Principal InvestigatorDawn Wahezi, MD
Contact Marija Dionizovik-Dimanovski, MD

Email Contact
Trial DescriptionA Multicenter, Open-label, Randomized, Event-driven Study to Assess Efficacy, Safety and Pharmacokinetics of Macitentan Versus Standard of Care in Children With Pulmonary Arterial Hypertension (PAH) (TOMORROW) - Click here for more information16-10-366-01
Disease/ConditionHeart and Vascular Diseases
Lung Diseases
Pediatrics
Pulmonary Hypertension
Principal InvestigatorNicole Sutton, MD
Contact Chelsie Cornelius

Email Contact
Trial DescriptionA Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Subjects With Active Systemic Lupus Erythematosus - Click here for more information18-02-68-01E
Disease/ConditionAutoimmune Diseases
Dermatology
Lupus
Pediatrics
Rheumatic Diseases
Geriatrics
Principal InvestigatorChaim Putterman, MD
Contact Nicole Jordan

Email Contact
Trial DescriptionA Phase 2, Randomized, Double-Blind, Dose-Ranging Study to Determine the Pharmacokinetics, Safety and Tolerability of Vedolizumab IV in Pediatric Subjects With Ulcerative Colitis or Crohn's Disease - Click here for more information18-10-218-01
Disease/ConditionColitis and Crohn's Disease
Gastroenterology & Liver Diseases
Pediatrics
Inflammatory Bowel Disease
Principal InvestigatorJohn Thompson, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Phase 3 Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Patients w/Influenza A Infection - Click here for more information17-02-306-01
Disease/ConditionGeriatrics
Infectious Diseases
Influenza
Pediatrics
Principal InvestigatorPaul Riska, MD
Contact Bola Omotosho

Email Contact
Trial DescriptionA Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis - Click here for more information18-10-220-01
Disease/ConditionDermatology
Pediatrics
Skin Disorders
Geriatrics
Immune System Diseases
Principal InvestigatorHolly Kanavy, MD
Contact Jose Jaller

Email Contact
Trial DescriptionA Phase 3, Randomized, Open-Label, Multicenter Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD) - Click here for more information18-10-59-01
Disease/ConditionHematologic Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Metabolic Diseases
Nephrology
Urologic Diseases
Pediatrics
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionA Phase II Multi-Center, Randomized, Double-Blind, 24-Week, Parallel Group, Placebo-Controlled Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Children and Adolescents Age 5-17 With Autism Spectrum Disorder (ASD) - Click here for more information16-10-117-01
Disease/ConditionAutism Spectrum Disorder
Neurodevelopmental Disorders
Pediatrics
Psychiatry - Non Cancer
Mental Health and Disorders
Principal InvestigatorEric Hollander, MD
Contact Danya Schlussel

Email Contact
Trial DescriptionA Prospective, Observational, Non-Interventional, Post-Marketing, Patient Registry to Collect Data on Routine Clinical Care in Patients Treated With Cholbam®/Kolbam® (Cholic Acid) - Click here for more information17-08-442-01
Disease/ConditionGastroenterology & Liver Diseases
Pediatrics
Liver Diseases
Principal InvestigatorNadia Ovchinsky, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Randomized, Double-Blind, Placebo-Controlled, Multi-Center Pragmatic Clinical Trial To Evaluate The Effectiveness Of Low Dose Oral Methotrexate In Patients With Pediatric Crohn's Disease Initiating Anti-TNF Therapy (COMBINE) - Click here for more information2017-7692
Disease/ConditionColitis and Crohn's Disease
Gastroenterology & Liver Diseases
Inflammatory Bowel Disease
Pediatrics
Principal InvestigatorGitit Tomer, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) - Click here for more information2016-6694
Disease/ConditionAnemia
Blood Disorders and Diseases
Sickle Cell
Pediatrics
Genetic Disorders
Hematologic Diseases
Principal InvestigatorCaterina Minniti, MD
Contact Andrew Crouch

Email Contact
Trial DescriptionAn Observational, Multicenter Study of the Prevalence of Cerebrotendinous Xanthomatosis (CTX) in Patient Populations Diagnosed With Early-Onset Idiopathic Bilateral Cataracts - Click here for more information15-10-432-01
Disease/ConditionGenetic Disorders
Ophthalmic Diseases and Disorders
Pediatrics
Principal InvestigatorNorman Medow, MD
Contact Jose Rosado

Email Contact
Trial DescriptionARCHIVE: A registry for children with vasculitis: e-entry 08-04-111E
Disease/ConditionHeart and Vascular Diseases
Pediatrics
Rheumatic Diseases
Autoimmune Diseases
Principal InvestigatorMaria Yee, MD
Contact Marija Dionizovik-Dimanovski

Email Contact
Trial DescriptionAssessing the Efficacy of Virtual Reality Analgesia (VRA) in Pediatric Patients for Pain Control During Botox Injections for Spasticity Management: A Randomized Control Trial - Click here for more information2016-6501
Disease/ConditionAnesthesia and Pain Management
Pediatrics
Rehabilitation Medicine
Principal InvestigatorYuxi Chen, MD
Contact Beendu Pujar

Email Contact
Trial DescriptionAutism Genetics Network, Phase II: Increasing Representation of Human Diversity 2012-537
Disease/ConditionAutism Spectrum Disorder
Neurology
Pediatrics
Genetic Disorders
Principal InvestigatorSophie Molholm, PhD
Contact Danielle DeMaio
(718) 862-1860
Email Contact
Trial DescriptionBezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001) (MODIFY III) - Click here for more information17-10-212-01
Disease/ConditionImmune System Diseases
Infectious Diseases
Pediatrics
Principal InvestigatorDavid Goldman, MD
Contact Sonia Sheehan

Email Contact
Trial DescriptionChildhood Asthma Perception Study (CAPS) - Click here for more information2014-3257
Disease/ConditionAllergy & Immunology
Allergy and Immune Disorders
Asthma and other Respiratory Diseases
Pediatrics
Principal InvestigatorJonathan Feldman, PhD
Contact Jonathan Feldman, PhD

Email Contact
Trial DescriptionDefensin and Innate Mucosal Immune Mediator Expression in Pediatric Inflammatory Bowel Disease 2012-529
Disease/ConditionGastroenterology & Liver Diseases
Inflammatory Bowel Disease
Pediatrics
Principal InvestigatorGitit Tomer, MD
Contact Preeti Malik

Email Contact
Trial DescriptionEfficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker - Click here for more information2017-8362
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Nephrology
Pediatrics
Urologic Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionHydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial - Click here for more information2017-8570
Disease/ConditionAnemia
Hematologic Diseases
Pediatric Hematology/Oncology
Pediatrics
Genetic Disorders
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland

Email Contact
Trial DescriptionMolecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction - Click here for more information2018-8749
Disease/ConditionNeonatology
Pediatrics
Overweight, Obesity and Weight Loss
Principal InvestigatorMamta Fuloria, MD
Contact Sonia Sheehan

Email Contact
Trial DescriptionMulticenter, Open Label, Phase 3 Study of Tabelecleucel for Solid Organ Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE) - Click here for more information16-10-296-01
Disease/ConditionEpstein-Barr Virus (EBV)
Lymphoproliferative Disorders
Pediatric Hematology/Oncology
Pediatrics
Solid Organ Transplant (SOT) Complications
Immune System Diseases
Principal InvestigatorDavid Loeb, MD
Contact Elodie Benard

Email Contact
Trial DescriptionNephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network (NEPTUNE) - Click here for more information09-06-182
Disease/ConditionGeriatrics
Kidney Diseases (incl Chronic Kidney Disease)
Nephrotic Syndrome
Pediatrics
Urologic Diseases
Immune System Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionPeer Mentor Training to Reduce Hospitalizations for Children With Asthma - Click here for more information10-06-174E
Disease/ConditionLung Diseases
Pediatrics
Asthma and other Respiratory Diseases
Principal InvestigatorDeepa Rastogi, MD
Contact Deepa Rastogi, MD

Email Contact
Trial DescriptionPhase 2 Study: Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Children and Adolescents With Prader-Willi Syndrome - Click here for more information2017-8076
Disease/ConditionPsychiatry - Non Cancer
Nervous System Diseases
Child Development
Pediatrics
Genetic Disorders
Principal InvestigatorEric Hollander, MD
Contact Danya Schlussel

Email Contact
Trial DescriptionPhase III Multicenter Open-label Randomized Clinical Trial Comparing Everolimus and Low Dose Tacrolimus to Tacrolimus and Mycophenolate Mofetil at 6 mo Post-Transplant to Prevent Long-term Complications After Pediatric Heart Transplantation - Click here for more information2017-8626
Disease/ConditionHeart and Vascular Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Pediatrics
Urologic Diseases
Cardiovascular and Thoracic Surgery
Principal InvestigatorJacqueline Lamour, MD
Contact Helen Alexander

Email Contact
Trial DescriptionPromoting Asthma Guidelines and Management through Technology-Based Intervention and Care Coordination (PRAGMATIC) - Click here for more information2016-6258
Disease/ConditionAsthma and other Respiratory Diseases
Pediatrics
Lung Diseases
Principal InvestigatorMarina Reznik, MD
Contact Guadalupe Salazar

Email Contact
Trial DescriptionProtocol for a Research Sample Repository and for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies, and Marrow Toxic Injuries - Click here for more information2015-5698
Disease/ConditionHematologic Diseases
Neoplasms
Pediatric Hematology/Oncology
Pediatrics
Oncology (Medical/Hematologic)
Principal InvestigatorDavid Loeb, MD
Contact Marissa Green

Email Contact
Trial DescriptionSimple Bone Cysts in Kids (SBoCK) - Click here for more information2015-4768
Disease/ConditionBones, Muscles & Joints (Orthopaedics)
Orthopaedic Surgery
Pediatrics
Neoplasms
Musculoskeletal Diseases
Principal InvestigatorJacob Schulz, MD
Contact Regina Hanstein

Email Contact
Trial DescriptionStudy of Allogeneic EBV-CTLs in EBV-Associated Viremia or Malignancies - Click here for more information16-10-116-01
Disease/ConditionHematologic Diseases
Pediatrics
Principal InvestigatorDavid Loeb, MD
Contact Elodie Benard

Email Contact
Trial DescriptionVALENS: A Ph 1/2, Random'd, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate Safety/Preliminary Efficacy of AT342, an AAV8-Delivered Gene Transfer Therapy in Crigler-Najjar Syndrome Subjects Aged 1 Yr and Older - Click here for more information2017-7918
Disease/ConditionBrain and Neurological
Crigler-Najjar Syndrome
Gastroenterology & Liver Diseases
Heart and Vascular Diseases
Metabolic Diseases
Pediatrics
Principal InvestigatorNadia Ovchinsky, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionWeb-based Peer Mentor Training to Reduce Hospitalizations for Children with Asthma - Click here for more information2014-3962
Disease/ConditionAsthma and other Respiratory Diseases
Pediatrics
Lung Diseases
Principal InvestigatorDeepa Rastogi, MD
Contact Toni Tobias

Email Contact
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