Endocrinology and Diabetes

Research

Original clinical research is the culmination of the education, clinical work, and mentorship provided by the three-year endocrinology and diabetes fellowship at CHAM. Among our faculty are potential mentors for fellows, including those in pediatric endocrinology, adult endocrinology, obstetrics and gynecology, and other departments. Some faculty members are involved in clinical trials, while others have completed a year-long course in clinical research and/or quality improvement.

The schedule for didactics and clinics allows ample dedicated time for fellows to focus on their research in their second and third years. Each fellow meets a minimum of three times with a self-selected scholarly oversight committee to review their research plan, monitor progress, and provide feedback. Fellows are expected to produce an abstract, which will ideally be presented at a national and/or international meeting and turned into a full manuscript.

Previous fellows have won grants and teaching awards. They have given oral presentations and poster presentations at national and local meetings, as well as published case reports, reviews, and original research. Montefiore's Department of Pediatrics hosts a Pediatric Research Day in April where many fellows present their work to their colleagues. We are excited by the research our fellows produce through the rigorous combination of clinical experience, education and research.

Fellows with a particular interest in research may consider the Clinical Research Training Program.

Here are the projects of our current fellows and recent graduates:

Projects of Current and Past Fellows:

• Exploring Characteristics of Hyperglycemic Hyperosmolar States in Pediatric Patients with an Emphasis on Hypernatremia
• Vitamin D and calcium metabolism in the MIS-C patients following COVID infection
• Assessing the Effect of Insulin Degludec on Hemoglobin A1c in an urban population of patients with type 1 and type 2 diabetes
• Quality Improvement: Improving Awareness About Medical ID bracelets in children with diabetes
• Factors that Influence Change in BMI after treatment  of autoimmune thyroid disease in children and adolescents
• The Influence of Breakfast on Hormone Responses and Cognitive Performance, as assessed by CTET in lean and obese adolescent males
• Creating a novel humanized mouse model for Hashimoto’s thyroiditis
• Review of NHANES database for thyroid function test abnormalities in children with obesity
• Retrospective review applying 2015 criteria for thyroid nodule concerning sonographic features to previously reported pediatric thyroid nodules
• Interrogation of the Igf1 gene locus for genetic and epigenetic defects that underlie discordant serum IGF-1 levels of MRL/J and SM/J inbred mouse strains.
• Influence of morning nutrition on cognitive performance in children with obesity
• Developing protocol for pre-operative and post-operative evaluation and management for pediatric thyroidectomy
• Supporting Emerging Adults with Diabetes (SEAD) Program: A model for transition
• Quality improvement project to reduce time to subcutaneous insulin administration for inpatients with diabetes
• Incidence and Outcomes of Pituitary Microadenomas in Children with Short Stature/Growth Hormone Deficiency (accepted for publication in Hormone Research in Pediatrics)
• Prevalence of emergency medical identification (EMI) use and an intervention to improve the use of EMI in pediatric insulin-using diabetes patients
• Pediatric Endocrinologists’ Experiences with Continuous Glucose Monitors in Children with Type 1 Diabetes
• Insulin resistance and obstructive sleep apnea in adolescents with PCOS
• MRI and Ultrasound Imaging of the ovaries in adolescents with PCOS
• Non-invasive tissue-specific glucose uptake in pregnancy using the dual imaging of MRI and mPET

Collaborative Fellowship Projects

• Utility of Obtaining Serum Thyroid Function Tests (TFTs) in Neonates Born to Mothers with Thyroid Disease in the Setting of Newborn Screening for Congenital Hypothyroidism (Dr. Underland, Dr. Derrick, Dr. Kenigsberg)
• Quality improvement project to reduce time to subcutaneous insulin administration for inpatients with diabetes (Dr. Eng, Dr. Duhame)
• Quality improvement project to improve reporting of thyroid nodule concerning features in pediatric patients (Dr. Pitera, Dr. Estanislao, Dr. Derrick, Dr. Hussain)

Fellow Presentations and Publications:

• Eng L, Raisingani M, Kaul A, Mehta S, Prasad K, Shah B. Severe metabolic disturbance in an human immunodeficiency virus-exposed newborn: Possible effect of in utero antiretroviral exposure. Abstract and poster presented Endo Society 2016, Boston, MA (April 2016).
• Eng L, Silver E, Gangar M, Lam L. Severe hypocalcemia after thyroidectomy in pediatric patients: a single-center retrospective study. Poster presented at Children’s Hospital at Montefiore and Albert Einstein College of Medicine Pediatric Research Day 2019, Bronx, NY (April 2019) and at NYU Winthrop’s 9th Annual Pediatric Endocrinology Symposium, Mineola, NY (October 2019). 8. Eng L, Chen JS, Lam L. Is there an association between the detection method for pediatric thyroid nodules and the risk of malignancy? Poster accepted for presentation at Endo Society 2020, San Francisco, CA (March 2020).
• Chen J, Eng L, Lam L. Graves’ disease presenting as chronic diarrhea in a toddler. Platform presentation at Endo Society 2019, New Orleans, LA (March 2019).
• Jarreau Chen. Parental Knowledge and Perceptions of Obstructive Sleep Apnea in Children Poster Presentation, ESPR 2016, March 25, 2016, Philadelphia, PA
• Rebecca Geliebter, Dennis Chia, Kristina Derrick. Azathioprine for tertiary prevention of diabetes in patients with newly diagnosed type 1 diabetes. Poster presentation, NYC Regional diabetes meeting, June 1, 2018, New York, NY.
• Yogangi Malhotra; Kristina Derrick; Rebecca Geliebter; Beth Drzewiecki; Molly Regelmann. Premature Ovarian Hyperstimulation Syndrome(POHS) Associated with Atypical Rise in DHEA-Sulfate. Poster presentation, Pediatric Academic Society, May 7, 2018, Toronto, CA.
• Case of a girl with delayed puberty and inflammatory bowel disease. Kristina Derrick and Aristotle Panayiotopoulos. In: Adolescent Gynecology. Ed: Hina Talib. Springer. 2018. 
• A Case of Thyroid Storm Associated with Cardiomyopathy and Poststreptococcal Glomerulonephritis.Underland LJ, Villeda GA, Pal A, Lam L. Case Rep Pediatr. 2016;2016:7192359.
• Lim YH, Ovejero D, Derrick KM, Yale Center for Mendelian Genomics, Collins MT, Choate KA. Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy. J Am Acad Dermatol. 2016 Aug;75(2):420-7.
• Clinical utility of magnetic resonance imaging and ultrasonography for diagnosis of polycystic ovary syndrome in adolescent girls. Kenigsberg LE, Agarwal C, Sin S, Shifteh K, Isasi CR, Crespi R, Ivanova J, Coupey SM, Heptulla RA, Arens R. Fertil Steril. 2015 Nov;104(5):1302-9.e1-4. PMID 26354095.
• Thyrotoxic Periodic Paralysis in a Hispanic Young Adult Male. Kenigsberg L, Kogelman Y, Lam L. Ann Pediatr Child Health. 2015;3(3):1059.
• An unusual case of ambiguous genitalia. Nicoletta-Gentile M, Lam L, Gangat M, Kogelman Y. International journal of case reports and images. 2012;3(3):24.26. 
• Foster care and type 1 diabetes in the Bronx: a case series. Gangat M, Klein GW, Heptulla RA. J Pediatr Endocrinol Metab. 2012;25(7-8):775-9. PMID: 23155709
• Eng L, Raisingani M, Kaul A, Mehta S, Prasad K, Shah B. Severe metabolic disturbance in an human immunodeficiency virus-exposed newborn: Possible effect of in utero antiretroviral exposure. J Clin Neonatol. 2018; 7:158-61.
• Eng L, Underland L, Lam L. Intrathyroidal thymic tissue in an adolescent with Graves’ disease: Case report and review of current literature. Case Rep Pediatr. 2019 Apr; 8089714. PMID: 31065395.
• Eng L, Regelmann MO. Early onset primary adrenal insufficiency in males with adrenoleukodystrophy: Case series and literature review. J Pediatr. 2019 Aug; 211:211-214. PMID: 31101408.
• Eng L, Lam L. Thyroid function during the fetal and neonatal periods. Neoreviews. 2020 Jan; 21(1):e30-e36. PMID: 31894080.
• Eng L, Regelmann MO. Adrenoleukodystrophy in the era of newborn screening. Curr Opin Endocrinol Diabetes Obes. 2020 Feb; 27(1):47-55. PMID: 31789721.
• Duhame D, Zhou P. “Chromosome 15q13.3 Microdeletion and MAGEL2 Gene Mutation in A Pediatric Patient with Extreme Obesity and Tall Stature: A Case Report.” Poster presented at: Endocrine Society Annual Meeting, April 2019; New Orleans, LA.
• Duhame D, Baer T. "Myocardial Infarction preceded by Diabetic Muscle Infarction in an Adolescent Female: Not just a Disease of Adults." Poster presentation to be given at the 2020 Pediatric Endocrine Society Annual Meeting, April 24-27 2020, Fort Worth, TX. Conference canceled. Hormone Research in Pediatrics 2020 July, Vol #93
• Duhame D, Antal Z, Zhou P. “Long-term Follow-up and Treatment Outcomes of a 2 year-old-boy with Metastatic Testosterone-secreting Adrenocortical Carcinoma: Endocrine Considerations in Diagnosis, Monitoring, and Treatment.” ACCE, 2020. Pub Status: Accepted, in Process.
• Eng L, Duhame D, Underland L. "Timely Administration of Rapid-acting Insulin in Hospitalized Children with Diabetes: A Quality Improvement Project." Poster presentation to be given at the 2020 American Diabetes Association Annual Meeting, June 2020, Chicago, IL. Conference canceled. Diabetes, 69 (Supplement 1) Jun 2020.