Community & Population Health – Research | The Children's Hospital at Montefiore

Research

Contact Community & Population Health

Email Us

We use implementation science and community expertise to develop and deliver interventions to improve community health. Our team of faculty researchers, data analysts, and community experts are engaged with partners across Montefiore Einstein and with national and global collaborators. Across all of our projects and geographies, our shared mission is to deliver high quality health care and reduce health inequity.

Our current research focuses on:

Optimizing community health worker models to respond to health-related social needs
Addressing chronic diseases like asthma and diabetes and health-related social needs with integrated models
Evaluating changes in childhood mortality in West Africa following the implementation of an integrated primary care program
Identifying implementation strategies to integrate and scale health-related social needs screening in large health systems
Assessing training for residents on the Social Determinants of Health
Evaluating implementation outcomes, including cost and sustainability
Global learning for health equity

Publications

Haughton, J., Dabla, D., Goin, D.E., Singer, A.W., Faro, E.Z., Miziou, E., Kangni-Zovoin, A., Agoro, S., Ekouevi, D.K., Fiori, K.P., & Hirschhorn, L.R. (2024). A time series analysis of disruptions to maternal and child health care in northern Togo during the COVID-19 pandemic in the context of an integrated primary care program. Advances in Global Health, 3(1). https://doi.org/10.1525/agh.2024.2123937

Mahajan, L., Granados, N., Haines, A., Fiori, K., & Jariwala, S. (2024). Evaluating the relationship between health-related social needs, patient demographics, and access to biologics in patients with moderate-to-severe asthma in Bronx, NY. Journal of Asthma, 1–10. https://doi.org/10.1080/02770903.2024.2362865. PMID: 38832891

Islam, F., Rinke, M. L., Philips, K., Cabrera, K. I., Luke, M. J., Chandhoke, S., Friedland, S. E., Acholonu, R.G., McKenna, K. J., Braganza, S., & Fiori, K. P. (2024). Implementing Inpatient Social Needs Screening in an Urban Tertiary Care Children’s Hospital. Hospital Pediatrics, 14(6). https://doi.org/10.1542/hpeds.2023-007486. PMID: 38742306

Midura, D., Levano, S., Fiori, K. P., & Farber, B. A. (2024). Analysis of Social Determinants of health in the pediatric general surgical population of a Northeastern Urban Health System. Journal of Pediatric Surgery. https://doi.org/10.1016/j.jpedsurg.2024.04.018. PMID: 38760308

Fiori, K. P., Levano, S., Haughton, J., Whiskey-LaLanne, R., Telzak, A., Muleta, H., Vani, K., Chambers, E. C., & Racine, A. (2024). Advancing Social Care Integration in health systems with Community Health Workers: An implementation evaluation based in Bronx, New York. BMC Primary Care, 25(1). https://doi.org/10.1186/s12875-024-02376-7. PMCID: PMC11055265

Telzak, A., Levano, S., Haughton, J., Chambers, E. C., & Fiori, K. P. (2024). Understanding individual health-related social needs in the context of area-level social determinants of health: The case for granularity. Journal of Clinical and Translational Science, 8(1), e78. https://doi.org/10.1017/cts.2024.519. PMCID: PMC11091925

Eligulashvili, A., Darrell, M., Gordon, M., Jerome, W., Fiori, K. P., Congdon, S., & Duong, T. Q. (2024). Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and Neuropsychiatric Sequela. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-58430-y. PMCID: PMC10987523

McKenna, K. J., Fiori, K. P., & Chambers, E. C. (2024). Children with chronic health conditions and social needs: Investigating outcomes to drive health system improvements. Clinical Pediatrics. https://doi.org/10.1177/00099228241241896. PMID: 38554010

Radparvar, A. A., Vani, K., Fiori, K. P., Gupta, S., Chavez, P., Fisher, M., Sharma, G., Wolfe, D., & Bortnick, A. E. (2024). Hypertensive disorders of pregnancy: Innovative management strategies. JACC: Advances, 3(3). https://doi.org/10.1016/j.jacadv.2024.100864

Levano, S. R., Kraemer, J., Dabla, D., Miziou, E. A., Haughton, J., Jones, H. E., Teasdale, C., Ekouevi, D., Hirschhorn, L. R., & Fiori, K. P. (2024). Identifying determinants of under-five child mortality in northern Togo. Journal of Global Health, 14, 04019. https://doi.org/10.7189/jogh.14.04019. PMCID: PMC10832555

Shin, S. S., Shah, A., North-Kabore, J., Rowthorn, V., Fiori, K. P., Dudding, R., Plum, R. A., Parke, D. M., George, C., Thomas, S., Pinkett, R., Porter, K. M., Sirois, A., Cordeiro, V., & Ogbolu, Y. (2023). Global Learning for Health Equity: A survey of five global learning sites in the United States. Community Health Equity Research & Policy. https://doi.org/10.1177/2752535x231210046. PMID: 37947506

Fiori, K. P., Levano, S., Haughton, J., Whiskey, R., Telzak, A., Hodgson, S., Spurrell-Huss, E., & Stark, A. (2023). Learning in real world practice: Identifying implementation strategies to integrate health-related social needs screening within a large health system. Journal of Clinical and Translational Science, 7(1), 1–25. https://doi.org/10.1017/cts.2023.652. PMCID: PMC10643918

Berman, R. S., Nguyen, H.-A. T., Levano, S. R., & Fiori, K. P. (2023). Clinician champions’ influence on social needs screening volumes in pediatric practices. Clinical Pediatrics, 63(7), 936-941. https://doi.org/10.1177/00099228231200404. PMID: 37715698

Ballard, M., Olaniran, A., Iberico, M. M., Rogers, A., Thapa, A., Cook, J., Aranda, Z., French, M., Olsen, H. E., Haughton, J., Lassala, D., Carpenter Westgate, C., Malitoni, B., Juma, M., & Perry, H. B. (2023). Labour conditions in dual-cadre community health worker programmes: A systematic review. The Lancet Global Health, 11(10), e1598-e1608. https://doi.org/10.1016/s2214-109x(23)00357-1. PMID: 37734803

Telzak, A., Fiori, K. P., Chambers, E. C., Haughton, J., Levano, S., & Reznik, M. (2023). Unmet social needs and pediatric asthma severity in an urban primary care setting. Academic Pediatrics, 23(7), 1361–1367. https://doi.org/10.1016/j.acap.2023.02.009. PMID: 36858248

Gutierrez, A. K., Twito, V., Ni, J., Liu, J., Atrio, J., Rolston, R., Menezes, M., Dunbar, J., Talib, H., Nguyen, H.-A., Fiori, K. P., Cassese, T., Cervera-Hernandez, M. E., Zwerling, J., & Jariwala, S. (2023). The impact of a Twitter-supplemented educational intervention to promote training in social determinants of health among medical residents. Current Journal of Applied Science and Technology, 42(32), 1–13. https://doi.org/10.9734/cjast/2023/v42i324216

Luke, M. J., Fernandes, D. M., Leon Rodriguez, F. D., Acholonu, R. G., & Fiori, K. P. (2023). Caregiver perspectives on social needs screening and interventions in an urban children’s Hospital. Hospital Pediatrics, 13(8), 670–681. https://doi.org/10.1542/hpeds.2022-006736. PMID: 37483130

Shi, M., Fiori, K. P., Kim, R. S., Gao, Q., Umanski, G., Thomas, I., Telzak, A., & Chambers, E. C. (2023). Social Needs Assessment and linkage to community health workers in a large urban hospital system. Journal of Primary Care & Community Health, 14. https://doi.org/10.1177/21501319231166918. PMCID: PMC10126704

Azan, A., Stephens, J., Xie, X., Fiori, K. P., & Gover, M. (2023). Covid-19 and changes in reported social risk factors at a primary care practice in the South Bronx. Journal of Primary Care & Community Health, 14, 215013192211471. https://doi.org/10.1177/21501319221147136. PMCID: PMC9834620

Fiori, K. P., & Oyeku, S. O. (2022). Addressing racial, ethnic, and socioeconomic differences in real-world practice. Pediatrics, 150(6). https://doi.org/10.1542/peds.2022-058243. PMID: 36336641

Ogbolu, Y., Dudding, R., Fiori, K. P., North-Kabore, J., Parke, D., Plum, Rev. A., Shin, S., & Rowthorn, V. (2022). Global Learning for Health Equity: A literature review. Annals of Global Health, 88(1). https://doi.org/10.5334/aogh.3810. PMCID: PMC9585985

Faro, E. Z., Haughton, J., Lauria, M. E., Miziou, E., Singer, A., Dabla, D., Gbeleou, S., Ekouevi, D. K., Hirschhorn, L. R., & Fiori, K. P. (2022). A pragmatic approach to qualitative formative evaluation of an Integrated Primary Care Program in Togo, West Africa. Global Implementation Research and Applications, 2(3), 209–218. https://doi.org/10.1007/s43477-022-00055-2

Telzak, A., Chambers, E. C., Gutnick, D., Flattau, A., Chaya, J., McAuliff, K., & Rapkin, B. (2022). Health Care Worker Burnout and perceived capacity to address social needs. Population Health Management, 25(3), 352–361. https://doi.org/10.1089/pop.2021.0175. PMCID: PMC9232233

Hanna, D. B., Felsen, U. R., Anastos, K., Bauman, L. J., Fiori, K. P., Ginsberg, M. S., Watnick, D., & Chambers, E. C. (2022). Correction to: Association of social needs with uncontrolled viremia in people with HIV. AIDS and Behavior, 26(11), 3746–3746. https://doi.org/10.1007/s10461-022-03732-3. PMID: 35704126

Herrera, T., Fiori, K. P., Archer-Dyer, H., Lounsbury, D. W., & Wylie-Rosett, J. (2022). Social Determinants of health screening by preclinical medical students during the COVID-19 pandemic: Service-Based Learning Case Study. JMIR Medical Education, 8(1). https://doi.org/10.2196/32818. PMCID: PMC8804950

Heller, C. G., Rehm, C. D., Parsons, A. H., Chambers, E. C., Hollingsworth, N. H., & Fiori, K. P. (2021). The association between social needs and chronic conditions in a large, urban primary care population. Preventive Medicine, 153, 106752. https://doi.org/10.1016/j.ypmed.2021.106752. PMCID: PMC8595547

Garg, A., Brochier, A., Messmer, E., & Fiori, K. P. (2021). Clinical approaches to reducing material hardship due to poverty: Social risks/needs identification and interventions. Academic Pediatrics, 21(8). https://doi.org/10.1016/j.acap.2021.02.007. PMID: 34740423

Fiori, K. P., Lauria, M. E., Singer, A. W., Jones, H. E., Belli, H. M., Aylward, P. T., Agoro, S., Gbeleou, S., Sowu, E., Grunitzky-Bekele, M., Singham Goodwin, A., Morrison, M., Ekouevi, D. K., & Hirschhorn, L. R. (2021). An integrated primary care initiative for child health in Northern Togo. Pediatrics, 148(3). https://doi.org/10.1542/peds.2020-035493. PMID: 34452981

Fiori, K. P., Heller, C. G., Flattau, A., Harris-Hollingsworth, N. R., Parsons, A., Rinke, M. L., Chambers, E. C., Hodgson, S., Chodon, T., & Racine, A. D. (2021). Scaling-up social needs screening in practice: A retrospective, cross-sectional analysis of data from electronic health records from Bronx County, New York, USA. BMJ Open, 11(9), e053633. https://doi.org/10.1136/bmjopen-2021-053633. PMCID: PMC8483051

Sanderson, D., Braganza, S., Philips, K., Chodon, T., Whiskey, R., Bernard, P., Rich, A., & Fiori, K. P. (2021). “Increasing warm handoffs: Optimizing community-based referrals in primary care using QI methodology.” Journal of Primary Care & Community Health, 12, 215013272110238. https://doi.org/10.1177/21501327211023883. PMCID: PMC8202298

Chambers, E. C., McAuliff, K. E., Heller, C. G., Fiori, K. P., & Hollingsworth, N. (2021). Toward understanding social needs among primary care patients with uncontrolled diabetes. Journal of Primary Care & Community Health, 12. https://doi.org/10.1177/2150132720985044. PMCID: PMC7960895

Chambers, E. C., Heller, C., Fiori, K. P., McAuliff, K., & Rehm, C. D. (2020). Chronic pediatric health conditions among youth living in public housing and receiving care in a large hospital system in Bronx, NY. Global Pediatric Health, 7. https://doi.org/10.1177/2333794x20971164. PMCID: PMC7672759

Fiori, K. P., Heller, C. G., Rehm, C. D., Parsons, A., Flattau, A., Braganza, S., Lue, K., Lauria, M., & Racine, A. (2020). Unmet social needs and no-show visits in primary care in a US northeastern urban health system, 2018–2019. American Journal of Public Health, 110(S2), S242-S250. https://doi.org/10.2105/ajph.2020.305717. PMCID: PMC7362703

Dubois, M., Faro, E. Z., Lee, D. S., Katin, V., Kenkou, K., & Fiori, K. P. (2020). Integrating childhood TB: Applying the care delivery value chain to improve pediatric HIV/TB services in Togo, West Africa. AIDS Care, 32(11), 1445–1450. https://doi.org/10.1080/09540121.2020.1770672. PMCID: PMC7572731

Kaplowitz, E. T., Fiori, K. P., Lauria, M. E., Gbeleou, S., Miziou, A., Sowu, E., Schechter, J., & Jones, H. E. (2020). Sexual relationship power and socio-demographic factors predicting contraceptive use, antenatal visits and sick child health service use in northern Togo. Maternal and Child Health Journal, 24(7), 845–855. https://doi.org/10.1007/s10995-020-02948-w. PMCID: PMC7340338

Heller, C. G., Parsons, A. S., Chambers, E. C., Fiori, K. P., & Rehm, C. D. (2020). Social risks among primary care patients in a large urban health system. American Journal of Preventive Medicine, 58(4), 514–525. https://doi.org/10.1016/j.amepre.2019.11.011. PMCID: PMC7362999

Fiori, K. P., Rehm, C. D., Sanderson, D., Braganza, S., Parsons, A., Chodon, T., Whiskey, R., Bernard, P., & Rinke, M. L. (2020). Integrating social needs screening and community health workers in primary care: The Community Linkage to Care Program. Clinical Pediatrics, 59(6), 547–556. https://doi.org/10.1177/0009922820908589. PMCID: PMC7357198

Fiori, K. P., Patel, M., Sanderson, D., Parsons, A., Hodgson, S., Scholnick, J., Bathory, E., White-Davis, T., Wigod, N., Chodon, T., Rich, A., & Braganza, S. (2020). From policy statement to practice: Integrating Social Needs Screening and referral assistance with community health workers in an urban academic health center. Journal of Primary Care & Community Health, 10. https://doi.org/10.1177/2150132719899207. PMCID: PMC6940600

Lauria, M. E., Fiori, K. P., Jones, H. E., Gbeleou, S., Kenkou, K., Agoro, S., Agbèrè, A. D., Lue, K. D., & Hirschhorn, L. R. (2019). Assessing the integrated community-based Health Systems Strengthening Initiative in Northern Togo: A pragmatic effectiveness-implementation study protocol. Implementation Science, 14(1), 92. https://doi.org/10.1186/s13012-019-0921-3. PMCID: PMC6796416

Fiori, K. P., Belli, H. M., Lauria, M. E., Hirschhorn, L. R., Schechter, J., Hansman, E., Rajshekhar, N., Katin, V., Gbeleou, S., Grunitsky-Bekele, M., & Pitche, V. P. (2019). Implementing an integrated community based Health Systems Strengthening Approach to improve HIV survival in northern Togo. AIDS Care, 32(6), 705–713. https://doi.org/10.1080/09540121.2019.1626342. PMCID: PMC7357197

Fiori, K. P., Chodon, T., Whiskey, R., Larrier, E., Izes, J., Braganza, S, Selwyn, P. (2018). Advancing Community Health and Wellness in Primary Care: A Bronx Community Based Organization’s Experience Integrating Community Health Workers into Patient Centered Medical Homes within an Academic Medical Center. Global Journal of Health Education and Promotion—Special Issue, 18(1), s19-s36. http://faheinfo.org/node/11.

Fiori, K. P., Schechter, J., Gbeleou, S. C., Braganza, S., Rhatigan, J., Houndenou, S., Lopez, A., Bensen, E., & Hirschhorn, L. (2018). Closing the delivery gap: Operationalizing the care delivery value chain and continuous quality improvement for HIV/AIDS services in Kara, Togo. International Journal of Health Care Quality Assurance, 31(4), 327–336. https://doi.org/10.1108/ijhcqa-02-2017-0024. PMCID: 29790442

McCarthy, K. J., Braganza, S., Fiori, K. P., Gbeleou, C., Kpakpo, V., Lopez, A., Schechter, J., Singham Goodwin, A., & Jones, H. E. (2017). Identifying inequities in maternal and child health through risk stratification to inform health systems strengthening in northern Togo. PLOS ONE, 12(3), e0173445. https://doi.org/10.1371/journal.pone.0173445. PMCID: PMC5354273

Arnold, J., Samson, M., Schechter, J., Goodwin, A. S., Braganza, S., Sesso, G. C., Lopez, A., & Fiori, K. P. (2016). Getting there: Overcoming barriers to reproductive and maternal health services access in northern Togo-a qualitative study. World Medical & Health Policy, 8(3), 223–244. https://doi.org/10.1002/wmh3.195

Fiori, K. P., Schechter, J., Dey, M., Braganza, S., Rhatigan, J., Houndenou, S., Gbeleou, C., Palerbo, E., Tchangani, E., Lopez, A., Bensen, E., & Hirschhorn, L. R. (2016). Closing the delivery gaps in pediatric HIV care in Togo, West Africa: Using the care delivery value chain framework to direct quality improvement. AIDS Care, 28(sup2), 29–33. https://doi.org/10.1080/09540121.2016.1176678. PMCID: PMC4991220

Loccoh, E. C., Azouma, D., Fiori, K. P., Schechter, J., Gbeleou, S., & Hirschhorn, L. R. (2014). Patient-reported factors facilitating participation in prevention of mother to child transmission of HIV programs in Kara, Togo, West Africa. World Journal of AIDS, 04(04), 446–457. https://doi.org/10.4236/wja.2014.44053

Trial DescriptionA 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Disease/ConditionInflammatory Bowel Diseases
Crohn's Disease
Ulcerative Colitis
Indeterminate Colitis

Principal InvestigatorGitit Tomer

Contact
9842340268
Email Contact

Trial DescriptionA 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Disease/ConditionInflammatory Bowel Diseases
Crohn's Disease
Ulcerative Colitis
Indeterminate Colitis

Principal InvestigatorGitit Tomer

Contact
9842340268
Email Contact

Trial DescriptionA Comprehensive Approach to Improve Medication Adherence in Pediatric ALL

Disease/ConditionAcute Lymphoblastic Leukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Comprehensive Approach to Improve Medication Adherence in Pediatric ALL

Disease/ConditionAcute Lymphoblastic Leukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Double-Blind, Placebo-Controlled, Multi-Center Study With an Open-Label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients With Duchenne Muscular Dystrophy

Disease/ConditionDuchenne Muscular Dystrophy

Principal InvestigatorVolkan Granit

Contact
Email Contact

Trial DescriptionA Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)

Disease/ConditionNonalcoholic Fatty Liver
Nonalcoholic Steatohepatitis

Principal InvestigatorPreeti Viswanathan

Contact
Email Contact

Trial DescriptionA Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)

Disease/ConditionNonalcoholic Fatty Liver
Nonalcoholic Steatohepatitis

Principal InvestigatorPreeti Viswanathan

Contact
Email Contact

Trial DescriptionA LONG-TERM, OPEN-LABEL FOLLOW-UP STUDY OF TOFACITINIB FOR TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS (JIA)

Disease/ConditionJuvenile Idiopathic Arthritis

Principal InvestigatorDawn Wahezi

Contact
Email Contact

Trial DescriptionA LONG-TERM, OPEN-LABEL FOLLOW-UP STUDY OF TOFACITINIB FOR TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS (JIA)

Disease/ConditionJuvenile Idiopathic Arthritis

Principal InvestigatorDawn Wahezi

Contact
Email Contact

Trial DescriptionA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

Disease/ConditionHematologic Malignancies
Inherited Disorders of Metabolism
Inherited Abnormalities of Platelets
Histiocytic Disorders
Acute Myelogenous Leukemia (AML or ANLL)
Acute Lymphoblastic Leukemia (ALL)
Other Acute Leukemia
Chronic Myelogenous Leukemia (CML)
Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases
Other Leukemia
Hodgkin Lymphoma
Non-hodgkin Lymphoma
Multiple Myeloma/ Plasma Cell Disorder (PCD)
Inherited Abnormalities of Erythrocyte Differentiation or Function
Disorders of the Immune System
Autoimmune Diseases
Severe Aplastic Anemia

Principal InvestigatorDavid Loeb

Contact
Email Contact

Principal InvestigatorDavid Loeb

Contact
Email Contact

Trial DescriptionA Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units Manufactured by the National Cord Blood Program and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients

Disease/ConditionInfusion Reactions

Principal InvestigatorDavid Loeb

Contact
718-706-5202
Email Contact

Disease/ConditionInfusion Reactions

Principal InvestigatorDavid Loeb

Contact
718-706-5202
Email Contact

Trial DescriptionA Multicenter, Open-label, Randomized, Study With Single-arm Extension Period to Assess the Pharmacokinetics, Safety and Efficacy of Macitentan Versus Standard of Care in Children With Pulmonary Arterial Hypertension

Disease/ConditionPulmonary Arterial Hypertension

Principal InvestigatorNicole Sutton

Contact
Email Contact

Disease/ConditionPulmonary Arterial Hypertension

Principal InvestigatorNicole Sutton

Contact
Email Contact

Trial DescriptionA Multi-center, Randomized, Placebo-Controlled Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of Belimumab, a Human Monoclonal Anti-BLyS Antibody, Plus Standard Therapy in Pediatric Patients With Systemic Lupus Erythematosus

Disease/ConditionSystemic Lupus Erythematosus

Principal InvestigatorDawn Wahezi

Contact
Email Contact

Disease/ConditionSystemic Lupus Erythematosus

Principal InvestigatorDawn Wahezi

Contact
Email Contact

Trial DescriptionA Phase 1, First-in-Human, Dose Escalation and Expansion Study to Evaluate the Safety and Tolerability of XmAb®541 in Advanced Solid Tumors

Disease/ConditionOvarian Cancer
Endometrial Cancer
Germ Cell Tumor
Testicular Germ Cell Tumor
Ovarian Germ Cell Tumor

Principal InvestigatorEric Feldman

Contact
1-858-945-2415
Email Contact

Trial DescriptionA Phase 1/2, Open-label, Dose-Escalation and Dose-Expansion Cohort Study of SNDX-5613 in Patients With Relapsed/Refractory Leukemias, Including Those Harboring an MLL/KMT2A Gene Rearrangement or Nucleophosmin 1 (NPM1) Mutation

Disease/ConditionAcute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Mixed Lineage Acute Leukemia
Mixed Phenotype Acute Leukemia
Acute Leukemia of Ambiguous Lineage

Principal InvestigatorIoannis Mantzaris

Contact
781-419-1400
Email Contact

Trial DescriptionA Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab With or Without Eflornithine (DFMO) in Children With Relapsed, Refractory or Progressive Neuroblastoma

Disease/ConditionHigh Risk Neuroblastoma
Recurrent Neuroblastoma
Refractory Neuroblastoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab With or Without Eflornithine (DFMO) in Children With Relapsed, Refractory or Progressive Neuroblastoma

Disease/ConditionHigh Risk Neuroblastoma
Recurrent Neuroblastoma
Refractory Neuroblastoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 2 Study of Dabrafenib (NSC# 763760) With Trametinib (NSC# 763093) After Local Irradiation in Newly-Diagnosed BRAF V600-Mutant High-Grade Glioma (HGG)

Disease/ConditionAnaplastic Astrocytoma
Anaplastic Astrocytoma, Not Otherwise Specified
Anaplastic Ganglioglioma
Anaplastic Pleomorphic Xanthoastrocytoma
Glioblastoma
Malignant Glioma
WHO Grade 3 Glioma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

Disease/ConditionMedulloblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia

Disease/ConditionLeukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase 2,Multicenter,Open-Label Study to Assess Appropriate Dosing and to Evaluate Safety of Crizanlizumab,With or Without Hydroxyurea/Hydroxycarbamide,in Sequential,Descending Age Groups of Pediatric Sickle Cell Disease Patients With Vaso-Occlusive Crisis

Disease/ConditionSickle Cell Disease (SCD)

Principal InvestigatorDeepa Manwani

Contact
Email Contact

Trial DescriptionA Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease

Disease/ConditionProteinuric Kidney Disease

Principal InvestigatorMichael Ross

Contact
617-341-6777
Email Contact

Trial DescriptionA Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients With Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) That Are Causing Significant Morbidity

Disease/ConditionPlexiform Neurofibroma
Neurofibromatosis Type 1 (NF1)

Principal InvestigatorNagma Dalvi

Contact
Email Contact

Trial DescriptionA Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

Disease/ConditionUlcerative Colitis (UC)

Principal InvestigatorThomas Ullman

Contact
Email Contact

Trial DescriptionA Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

Disease/ConditionUlcerative Colitis (UC)

Principal InvestigatorThomas Ullman

Contact
Email Contact

Trial DescriptionA Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

Disease/ConditionLow Grade Astrocytoma
Low Grade Glioma
Metastatic Low Grade Astrocytoma
Metastatic Low Grade Glioma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

Disease/ConditionLow Grade Glioma
Neurofibromatosis Type 1
Visual Pathway Glioma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase 3 Randomized Trial for Patients With De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 With GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients With FLT3 Mutations

Disease/ConditionAcute Myeloid Leukemia

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy

Disease/ConditionB Acute Lymphoblastic Leukemia
B Lymphoblastic Lymphoma
Central Nervous System Leukemia
Mixed Phenotype Acute Leukemia
Testicular Leukemia

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis

Disease/ConditionAtopic Dermatitis

Principal InvestigatorHolly Kanavy

Contact
Email Contact

Trial DescriptionA Phase 3 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo With the BB305 Lentiviral Vector in Subjects With Sickle Cell Disease

Disease/ConditionSickle Cell Disease

Principal InvestigatorDeepa Manwani

Contact
+1-833-999-6378
Email Contact

Trial DescriptionA Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or ALK Inhibitor Therapy Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL)

Disease/ConditionGanglioneuroblastoma
Neuroblastoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors

Disease/ConditionChildhood Extracranial Germ Cell Tumor
Extragonadal Embryonal Carcinoma
Germ Cell Tumor
Malignant Germ Cell Tumor
Malignant Ovarian Teratoma
Stage I Ovarian Choriocarcinoma
Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7
Stage I Ovarian Teratoma AJCC v6 and v7
Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7
Stage I Testicular Choriocarcinoma AJCC v6 and v7
Stage I Testicular Embryonal Carcinoma AJCC v6 and v7
Stage I Testicular Seminoma AJCC v6 and v7
Stage I Testicular Yolk Sac Tumor AJCC v6 and v7
Stage II Ovarian Choriocarcinoma
Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7
Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7
Stage II Testicular Choriocarcinoma AJCC v6 and v7
Stage II Testicular Embryonal Carcinoma AJCC v6 and v7
Stage II Testicular Yolk Sac Tumor AJCC v6 and v7
Stage III Ovarian Choriocarcinoma
Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7
Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7
Stage III Testicular Choriocarcinoma AJCC v6 and v7
Stage III Testicular Embryonal Carcinoma AJCC v6 and v7
Stage III Testicular Yolk Sac Tumor AJCC v6 and v7
Stage IV Ovarian Choriocarcinoma
Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7
Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7
Testicular Mixed Choriocarcinoma and Embryonal Carcinoma
Testicular Mixed Choriocarcinoma and Teratoma
Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Phase 3, Double-Blind, Multicenter, Randomized Study to Evaluate the Efficacy and Safety of Subcutaneous Twice Yearly Long-Acting Lenacapavir for HIV Pre-Exposure Prophylaxis in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People ≥ 16 Years of Age Who Have Sex With Male Partners and Are at Risk for HIV Infection

Disease/ConditionPre-Exposure Prophylaxis of HIV Infection

Principal InvestigatorMichelle Collins-Ogle

Contact
Email Contact

Trial DescriptionA Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of Baricitinib in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata

Disease/ConditionAreata Alopecia
Alopecia
Hypotrichosis
Hair Diseases
Skin Diseases
Pathological Conditions, Anatomical

Principal InvestigatorHolly Kanavy

Contact
-317-615-4559
Email Contact

Trial DescriptionA Phase 3, Open-label, Long-term Safety Study of Oral Linaclotide Administered to Pediatric Participants With Functional Constipation (FC) or Irritable Bowel Syndrome With Constipation (IBS-C)

Disease/ConditionIrritable Bowel Syndrome With Constipation
Functional Constipation

Principal InvestigatorJohn Thompson

Contact
Email Contact

Trial DescriptionA Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Migraine Prevention in Children and Adolescents ≥ 6 to <18 Years of Age

Disease/ConditionMigraine

Principal InvestigatorJelena Pavlovic

Contact
1-800-718-1021
Email Contact

Trial DescriptionA Phase 3, Randomized, Open-Label, Multicenter Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)

Disease/ConditionChronic Kidney Disease; Iron Deficiency Anemia

Principal InvestigatorAnna Zolotnitskaya

Contact
1-877-374 -4177
Email Contact

Disease/ConditionChronic Kidney Disease; Iron Deficiency Anemia

Principal InvestigatorAnna Zolotnitskaya

Contact
1-877-374 -4177
Email Contact

Trial DescriptionA Phase II Trial of Reduced Intensity Conditioning and Partially HLA-mismatched (HLA-haploidentical) Related Donor Bone Marrow Transplantation for High-risk Solid Tumors

Disease/ConditionRefractory and/or Relapsed Metastatic Solid Tumors

Principal InvestigatorDavid Loeb

Contact
410-502-4997
Email Contact

Trial DescriptionA Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma

Disease/ConditionMelanoma of Unknown Primary
Recurrent Melanoma
Stage IIIB Cutaneous Melanoma AJCC v7
Stage IIIC Cutaneous Melanoma AJCC v7
Stage IV Cutaneous Melanoma AJCC v6 and v7

Principal InvestigatorJoseph Sparano

Contact
Email Contact

Trial DescriptionA Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma

Disease/ConditionMelanoma of Unknown Primary
Recurrent Melanoma
Stage IIIB Cutaneous Melanoma AJCC v7
Stage IIIC Cutaneous Melanoma AJCC v7
Stage IV Cutaneous Melanoma AJCC v6 and v7

Principal InvestigatorJoseph Sparano

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia (B-ALL) Including a Stratum Evaluating Dasatinib (NSC#732517) in Patients With Ph-like Tyrosine Kinase Inhibitor (TKI) Sensitive Mutations

Disease/ConditionB Acute Lymphoblastic Leukemia
B Acute Lymphoblastic Leukemia, BCR-ABL1-Like
Central Nervous System Leukemia
Testicular Leukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Disease/ConditionB Acute Lymphoblastic Leukemia
B Acute Lymphoblastic Leukemia, BCR-ABL1-Like
Central Nervous System Leukemia
Testicular Leukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial for Patients With De Novo AML Using Bortezomib and Sorafenib (NSC# 681239, NSC# 724772) for Patients With High Allelic Ratio FLT3/ITD

Disease/ConditionAcute Myeloid Leukemia
Leukemia Cutis
Myeloid Neoplasm
Myeloid Sarcoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial for Patients With De Novo AML Using Bortezomib and Sorafenib (NSC# 681239, NSC# 724772) for Patients With High Allelic Ratio FLT3/ITD

Disease/ConditionAcute Myeloid Leukemia
Leukemia Cutis
Myeloid Neoplasm
Myeloid Sarcoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 Months Old With Intensive Induction Chemotherapy With Methotrexate Followed by Consolidation With Stem Cell Rescue vs. the Same Therapy Without Methotrexate

Disease/ConditionAnaplastic Medulloblastoma
Medulloblastoma
Supratentorial Embryonal Tumor, Not Otherwise Specified
Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

Principal InvestigatorJonathan Gill

Contact
Email Contact

Disease/ConditionAnaplastic Medulloblastoma
Medulloblastoma
Supratentorial Embryonal Tumor, Not Otherwise Specified
Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor

Principal InvestigatorJonathan Gill

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial Investigating Bortezomib (NSC# 681239) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T-Lymphoblastic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LLy)

Disease/ConditionAdult T Acute Lymphoblastic Leukemia
Ann Arbor Stage II Adult Lymphoblastic Lymphoma
Ann Arbor Stage II Childhood Lymphoblastic Lymphoma
Ann Arbor Stage III Adult Lymphoblastic Lymphoma
Ann Arbor Stage III Childhood Lymphoblastic Lymphoma
Ann Arbor Stage IV Adult Lymphoblastic Lymphoma
Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma
Childhood T Acute Lymphoblastic Leukemia

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

Disease/ConditionLocalized Extraskeletal Ewing Sarcoma
Peripheral Primitive Neuroectodermal Tumor of Bone
Peripheral Primitive Neuroectodermal Tumor of Soft Tissues

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

Disease/ConditionLocalized Extraskeletal Ewing Sarcoma
Peripheral Primitive Neuroectodermal Tumor of Bone
Peripheral Primitive Neuroectodermal Tumor of Soft Tissues

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide and All-Trans Retinoic Acid

Disease/ConditionAcute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

Disease/ConditionAnn Arbor Stage III Hodgkin Lymphoma
Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma
Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma
Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma
Ann Arbor Stage IV Hodgkin Lymphoma
Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma
Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma
Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma
Classic Hodgkin Lymphoma
Lymphocyte-Rich Classic Hodgkin Lymphoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Prospective Observational Study of Patients Receiving DUPIXENT® for Atopic Dermatitis

Disease/ConditionDermatitis, Atopic

Principal InvestigatorHolly Kanavy

Contact
Email Contact

Trial DescriptionA Prospective, Long-Term Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

Disease/ConditionSpinal Muscular Atrophy (SMA)

Principal InvestigatorLESLIE DELFINER

Contact
1-888-669-6682
Email Contact

Trial DescriptionA Prospective, Multi-center Registry for Patients With Short Bowel Syndrome

Disease/ConditionShort Bowel Syndrome

Principal InvestigatorJohn Thompson

Contact
Email Contact

Trial DescriptionA Prospective, Multi-center Registry for Patients With Short Bowel Syndrome

Disease/ConditionShort Bowel Syndrome

Principal InvestigatorJohn Thompson

Contact
Email Contact

Trial DescriptionA Prospective, Observational, Non-Interventional, Post-Marketing, Patient Registry to Collect Data on Routine Clinical Care in Patients Treated With Cholbam® (Cholic Acid)

Disease/ConditionBile Acid Synthesis Disorders

Principal InvestigatorNadia Ovchinsky

Contact
Email Contact

Trial DescriptionA Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

Disease/ConditionChondral Defect
Osteochondritis Dissecans (OCD)
Articular Cartilage Defect
Articular Cartilage Disorder of Knee

Principal InvestigatorEric Fornari

Contact
484-387-2257
Email Contact

Disease/ConditionChondral Defect
Osteochondritis Dissecans (OCD)
Articular Cartilage Defect
Articular Cartilage Disorder of Knee

Principal InvestigatorEric Fornari

Contact
484-387-2257
Email Contact

Trial DescriptionA Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma

Disease/ConditionLugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Randomized Phase 3 Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Young Adults

Disease/ConditionAnn Arbor Stage IIB Hodgkin Lymphoma
Ann Arbor Stage IIIB Hodgkin Lymphoma
Ann Arbor Stage IVA Hodgkin Lymphoma
Ann Arbor Stage IVB Hodgkin Lymphoma
Childhood Hodgkin Lymphoma
Classic Hodgkin Lymphoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Randomized Phase 3 Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Young Adults

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS)

Disease/ConditionAlveolar Rhabdomyosarcoma
Botryoid-Type Embryonal Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
Rhabdomyosarcoma
Sclerosing Rhabdomyosarcoma
Spindle Cell Rhabdomyosarcoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

Disease/ConditionPrimary Mediastinal Large B-Cell Lymphoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionA Randomized Study of Dexamethasone as Adjuvant Therapy for Acute Post-traumatic Headache

Disease/ConditionPost-Traumatic Headache

Principal InvestigatorBenjamin Friedman

Contact
718-920-6626
Email Contact

Trial DescriptionA Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years

Disease/ConditionBowel Preparation

Principal InvestigatorInna Novak

Contact
+1 833-548-1402 (US/Canada)
Email Contact

Trial DescriptionA Randomized, Comparative Effectiveness Study of Staged Complete Revascularization With Percutaneous Coronary Intervention to Treat Coronary Artery Disease vs Medical Management Alone in Patients With Symptomatic Aortic Valve Stenosis Undergoing Elective Transfemoral Transcatheter Aortic Valve Replacement: The COMPLETE TAVR Study

Disease/ConditionAortic Stenosis
Coronary Artery Disease
Coronary Stenosis

Principal InvestigatorMark Menegus

Contact
604-875-4111
Email Contact

Trial DescriptionA Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study

Disease/ConditionNecrotizing Enterocolitis

Principal InvestigatorShantanu Rastogi

Contact
Email Contact

Trial DescriptionA Randomized, Double-Blind Evaluation of the Pharmacokinetics, Safety, and Antiviral Efficacy of Tenofovir Alafenamide (TAF) in Children and Adolescent Subjects With Chronic Hepatitis B Virus Infection

Disease/ConditionChronic Hepatitis B

Principal InvestigatorDebra Pan

Contact
Email Contact

Trial DescriptionA Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter Variable Length Study to Assess the Efficacy and Safety of PT010 Relative to PT009 and Symbicort® in Adult and Adolescent Participants With Inadequately Controlled Asthma

Disease/ConditionAsthma

Principal InvestigatorGolda Hudes

Contact
Email Contact

Trial DescriptionA Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Carisbamate (YKP509) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults, With Optional Open-Label Extension

Disease/ConditionSeizures
Lennox Gastaut Syndrome

Principal InvestigatorAlexis Boro

Contact
201-421-3810
Email Contact

Trial DescriptionA Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Extended-release Tablets n Pediatric Subjects Aged 5 to 17 Years With Active, Mild to Moderate Ulcerative Colitis

Disease/ConditionUlcerative Colitis

Principal InvestigatorGitit Tomer

Contact
9082428287
Email Contact

Trial DescriptionA Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine After Allogeneic Stem Cell Transplantation in Subjects With Acute Myeloid Leukemia (AML) (VIALE-T)

Disease/ConditionAcute Myeloid Leukemia (AML)
Cancer

Principal InvestigatorIoannis Mantzaris

Contact
Email Contact

Trial DescriptionA Safety, Pharmacokinetic and Efficacy Study of a y-Secretase Inhibitor, Nirogacestat (PF-03084014), in Children and Adolescents With Progressive, Surgically Unresectable Desmoid Tumors

Disease/ConditionDesmoid Fibromatosis
Recurrent Desmoid Fibromatosis
Unresectable Desmoid Fibromatosis

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Disease/ConditionDesmoid Fibromatosis
Recurrent Desmoid Fibromatosis
Unresectable Desmoid Fibromatosis

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionA Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00 Gy) and Chemotherapy in Children With Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial

Disease/ConditionMedulloblastoma

Principal InvestigatorPeter Cole

Contact
Email Contact

Disease/ConditionMedulloblastoma

Principal InvestigatorPeter Cole

Contact
Email Contact

Trial DescriptionACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve Through Implantation of ACURATE in Subjects InDicatEd for TAVR

Disease/ConditionAortic Stenosis

Principal InvestigatorMohamed Azeem Latib

Contact
Email Contact

Trial DescriptionAn Open Label Extension Study of Voxelotor (GBT440) Administered Orally to Participants With Sickle Cell Disease Who Have Participated in Voxelotor Clinical Trials

Disease/ConditionSickle Cell Disease

Principal InvestigatorCaterina Minniti

Contact
Email Contact

Trial DescriptionAn Open-Label Extension Study of CM-AT for the Treatment of Children With Autism With All Levels of Fecal Chymotrypsin

Disease/ConditionAutism

Principal InvestigatorEric Hollander

Contact
Email Contact

Trial DescriptionAn Open-Label Extension Study of CM-AT for the Treatment of Children With Autism With All Levels of Fecal Chymotrypsin

Disease/ConditionAutism

Principal InvestigatorEric Hollander

Contact
Email Contact

Trial DescriptionAn Open-label Extension Study to Evaluate the Long-term Safety and Efficacy of Maralixibat in the Treatment of Subjects with Progressive Familial Intrahepatic Cholestasis (PFIC)

Disease/ConditionProgressive Familial Intrahepatic Cholestasis (PFIC)

Principal InvestigatorNadia Ovchinsky

Contact
Email Contact

Trial DescriptionAn Open-label, First-in-human, Dose-escalation/Expansion Study of SAR443579 Administered as Single Agent by Intravenous Infusion in Adult and Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Disease/ConditionAcute Lymphocytic Leukaemia
Acute Myeloid Leukaemia Refractory
Myelodysplastic Syndromes
Blastic Plasmacytoid Dendritic Cell Neoplasia

Principal InvestigatorIoannis Mantzaris

Contact
800-633-1610
Email Contact

Trial DescriptionAn Open-label, Single-arm, Multicohort, Phase 2 Study to Assess the Efficacy and Safety of Tabelecleucel in Subjects with Epstein-Barr Virus-associated Diseases (EBVision)

Disease/ConditionEpstein-Barr Virus (EBV)-associated Diseases
EBV+ Lymphoproliferative Disease with Primary Immunodeficiency (EBV+ PID LPD)
EBV+ Lymphoproliferative Disease with Acquired (non-congenital) Immunodeficiency (EBV+ AID LPD)
EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
Solid Organ Transplant Complications
Lymphoproliferative Disorders
Allogeneic Hematopoietic Cell Transplant
Stem Cell Transplant Complications
EBV+ Sarcomas
Leiomyosarcoma

Principal InvestigatorDavid Loeb

Contact
650-278-8930
Email Contact

Trial DescriptionAPOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

Disease/ConditionKidney Diseases
Kidney Failure
Kidney Disease, Chronic

Principal InvestigatorEnver Akalin

Contact
336-713-4292
Email Contact

Trial DescriptionAssessment of CMV-specific T Cell Responses by Flow Cytometry With Intracellular Cytokine Staining to Predict CMV Infection Risk in Pediatric Solid Organ Transplant Recipients

Disease/ConditionHeart Transplant Infection
Kidney Transplant Infection
Liver Transplant Infection
CMV

Principal InvestigatorBetsy Herold

Contact
Email Contact

Trial DescriptionCancer Moonshot Biobank Research Protocol

Disease/ConditionAcute Myeloid Leukemia
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
Clinical Stage IV Gastric Cancer AJCC v8
Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
Lung Non-Small Cell Carcinoma
Lung Small Cell Carcinoma
Malignant Solid Neoplasm
Metastatic Prostate Carcinoma
Multiple Myeloma
Stage III Lung Cancer AJCC v8
Stage III Ovarian Cancer AJCC v8
Stage IV Colorectal Cancer AJCC v8
Stage IV Lung Cancer AJCC v8
Stage IV Ovarian Cancer AJCC v8
Stage IV Prostate Cancer AJCC v8
Stage IVB Prostate Cancer AJCC v8

Principal InvestigatorBalazs Halmos

Contact
Email Contact

Trial DescriptionCannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)

Disease/ConditionAutism Spectrum Disorder

Principal InvestigatorEric Hollander

Contact
914-315-4236
Email Contact

Trial DescriptionCannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)

Disease/ConditionAutism Spectrum Disorder

Principal InvestigatorEric Hollander

Contact
914-315-4236
Email Contact

Trial DescriptionChronic Health Conditions in Down Syndrome-Associated Acute Leukemia: The Down Syndrome Phenotyping Acute Leukemia Study in Survivors (DS-PALS Survivors)

Disease/ConditionB Acute Lymphoblastic Leukemia Associated With Down Syndrome
Down Syndrome
Myeloid Leukemia Associated With Down Syndrome

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionChronic Kidney Disease in Children Prospective Cohort Study (CKiD)

Disease/ConditionChronic Kidney Disease

Principal InvestigatorFrederick Kaskel

Contact
Email Contact

Trial DescriptionChronic Kidney Disease in Children Prospective Cohort Study (CKiD)

Disease/ConditionChronic Kidney Disease

Principal InvestigatorFrederick Kaskel

Contact
Email Contact

Trial DescriptionComparison of Conventional Non-Invasive Ventilation and Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Ventilation for the Treatment of Bronchiolitis

Disease/ConditionBronchiolitis

Principal InvestigatorJacqueline Weingarten-Arams

Contact
2017459825
Email Contact

Trial DescriptionDocumentation and Delivery of Guideline-Consistent Treatment in Adolescent and Young Adult (AYA) Acute Lymphoblastic Leukemia (ALL)

Disease/ConditionAcute Lymphoblastic Leukemia

Principal InvestigatorDavid Loeb

Contact
Email Contact

Trial DescriptionEffect of IL-4RαR576 Polymorphism on Response to Dupilumab in Asthma, a Genotype-stratified, Randomized, Placebo- Controlled Trial

Disease/ConditionAsthma

Principal InvestigatorSunit Jariwala

Contact
857-218-5336
Email Contact

Trial DescriptionEfficacy & Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis- a Double-Blind Placebo Controlled Clinical Trial

Disease/ConditionLupus Nephritis

Principal InvestigatorDawn Wahezi

Contact
513-803-2118
Email Contact

Trial DescriptionEfficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

Disease/ConditionAnaplastic Medulloblastoma
Medulloblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionEfficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

Disease/ConditionAnaplastic Medulloblastoma
Medulloblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionEROS: Engendering Reproductive Health Within Oncologic Survivorship

Disease/ConditionMalignant Neoplasm

Principal InvestigatorDella Makower

Contact
Email Contact

Trial DescriptionEROS: Engendering Reproductive Health Within Oncologic Survivorship

Disease/ConditionMalignant Neoplasm

Principal InvestigatorDella Makower

Contact
Email Contact

Trial DescriptionEstablishing Continuous Cell Lines and Xenografts From Pediatric Cancers for Biological and Pre-Clinical Therapeutic Studies

Disease/ConditionAcute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Central Nervous System Neoplasm
Ewing Sarcoma
Germ Cell Tumor
Leukemia
Lymphoma
Malignant Neoplasm
Neuroblastoma
Osteosarcoma
Retinoblastoma
Rhabdoid Tumor
Rhabdomyosarcoma
Soft Tissue Sarcoma

Principal InvestigatorPeter Cole

Contact
Email Contact

Trial DescriptionEstablishing Continuous Cell Lines and Xenografts From Pediatric Cancers for Biological and Pre-Clinical Therapeutic Studies

Principal InvestigatorPeter Cole

Contact
Email Contact

Trial DescriptionEvaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)

Disease/ConditionAsthma in Children

Principal InvestigatorMarina Reznik

Contact
Email Contact

Trial DescriptionGenetic Modifiers of 22q11.2 Deletion Syndrome

Disease/ConditionDiGeorge Syndrome
22q11.2 Deletion Syndrome

Principal InvestigatorBernice Morrow

Contact
914-329-4653
Email Contact

Trial DescriptionGenetic Modifiers of 22q11.2 Deletion Syndrome

Disease/ConditionDiGeorge Syndrome
22q11.2 Deletion Syndrome

Principal InvestigatorBernice Morrow

Contact
914-329-4653
Email Contact

Trial DescriptionImplementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

Disease/ConditionCongenital Heart Disease

Principal InvestigatorOmar Saeed

Contact
212-305-8509
Email Contact

Trial DescriptionImplementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

Disease/ConditionCongenital Heart Disease

Principal InvestigatorOmar Saeed

Contact
212-305-8509
Email Contact

Trial DescriptionLarotrectinib (LOXO-101, NSC# 788607) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias

Disease/ConditionCentral Nervous System Neoplasm
Infantile Fibrosarcoma
Recurrent Acute Leukemia
Refractory Acute Leukemia
Solid Neoplasm

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionLarotrectinib (LOXO-101, NSC# 788607) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias

Disease/ConditionCentral Nervous System Neoplasm
Infantile Fibrosarcoma
Recurrent Acute Leukemia
Refractory Acute Leukemia
Solid Neoplasm

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionLong-Term Follow-Up (LTFU) of Participants Treated With ADP Adoptive Cell Therapies

Disease/ConditionNeoplasms

Principal InvestigatorDavid Loeb

Contact
215-825-9260
Email Contact

Trial DescriptionLong-Term Follow-Up (LTFU) of Participants Treated With ADP Adoptive Cell Therapies

Disease/ConditionNeoplasms

Principal InvestigatorDavid Loeb

Contact
215-825-9260
Email Contact

Trial DescriptionMaster Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered NY-ESO-1-Specific (c259) T Cells, Alone or in Combination With Other Agents, in HLA-A2+ Participants With NY-ESO-1 and/or LAGE-1a Positive Solid Tumors (IGNYTE-ESO)

Disease/ConditionNeoplasms

Principal InvestigatorDavid Loeb

Contact
Email Contact

Trial DescriptionMatched Targeted Therapy (MTT) Recommendation for Patients With Recurrent, Refractory, or High Risk Leukemias and Myelodysplastic Syndrome

Disease/ConditionRecurrent, Refractory, or High Risk Leukemias
Matched Targeted Therapy

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionMatched Targeted Therapy (MTT) Recommendation for Patients With Recurrent, Refractory, or High Risk Leukemias and Myelodysplastic Syndrome

Disease/ConditionRecurrent, Refractory, or High Risk Leukemias
Matched Targeted Therapy

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionMetformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse

Disease/ConditionOsteosarcoma
Ewing Sarcoma

Principal Investigator

Contact
+39(051)6366668
Email Contact

Trial DescriptionMetformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse

Disease/ConditionOsteosarcoma
Ewing Sarcoma

Principal Investigator

Contact
+39(051)6366668
Email Contact

Trial DescriptionMinimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Disease

Disease/ConditionSickle Cell Disease

Principal InvestigatorMichelle Lee

Contact
202-476-5000
Email Contact

Trial DescriptionMOdern Treatment of Inhibitor-PositiVe PATiEnts With Haemophilia A - An International Observational Study

Disease/ConditionHemophilia A

Principal InvestigatorWilliam Mitchell

Contact
404-785-1637
Email Contact

Trial DescriptionMolecular Analysis for Combination Therapy Choice (ComboMATCH)

Disease/ConditionAdvanced Malignant Solid Neoplasm
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Locally Advanced Malignant Solid Neoplasm
Malignant Female Reproductive System Neoplasm
Metastatic HER2-Negative Breast Carcinoma
Metastatic Malignant Solid Neoplasm
Recurrent Endometrial Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Malignant Female Reproductive System Neoplasm
Recurrent Malignant Solid Neoplasm
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma
Unresectable HER2-Negative Breast Carcinoma
Unresectable Malignant Solid Neoplasm

Principal InvestigatorBalazs Halmos

Contact
Email Contact

Trial DescriptionMolecular and Genomic Profiling of Head and Neck Tumors to Explore Biomarkers Associated With Prognosis and Response to Therapy

Disease/ConditionHead and Neck Neoplasms

Principal InvestigatorRichard Smith

Contact
718-920-7054
Email Contact

Trial DescriptionMolecular and Genomic Profiling of Head and Neck Tumors to Explore Biomarkers Associated With Prognosis and Response to Therapy

Disease/ConditionHead and Neck Neoplasms

Principal InvestigatorRichard Smith

Contact
718-920-7054
Email Contact

Trial DescriptionMolecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

Disease/ConditionChildhood Obesity
Epigenetics

Principal InvestigatorMamta Fuloria

Contact
718-904-4105
Email Contact

Trial DescriptionMolecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

Disease/ConditionChildhood Obesity
Epigenetics

Principal InvestigatorMamta Fuloria

Contact
718-904-4105
Email Contact

Trial DescriptionMulti-Center African-American Inflammatory Bowel Disease Study (MAAIS)

Disease/ConditionInflammatory Bowel Disease

Principal InvestigatorRuby Greywoode

Contact
410-614-1982
Email Contact

Trial DescriptionMulticenter Cohort Study To Evaluate Outcomes After Receipt of Targeted Therapy Matched to an Individualized Cancer Therapy (iCat) Recommendations in Children and Young Adults With Solid Tumors: The iCat2, GAIN Consortium Study

Disease/ConditionPediatric Solid Tumor

Principal InvestigatorDaniel Weiser

Contact
Email Contact

Trial DescriptionMulticenter, Open-Label, Phase 3 Study of Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Subjects with Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy

Disease/ConditionEpstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
Solid Organ Transplant Complications
Lymphoproliferative Disorders
Allogeneic Hematopoietic Cell Transplant
Stem Cell Transplant Complications

Principal InvestigatorIoannis Mantzaris

Contact
650-278-8930
Email Contact

Trial DescriptionMulticenter, Prospective, Open-label, Randomized, Crossover Study to Evaluate Pharmacokinetics (PK), Safety, and Tolerability of TAK-881 in Primary Immunodeficiency Diseases (PIDD)

Disease/ConditionPrimary Immunodeficiency Diseases (PID)

Principal InvestigatorArye Rubinstein

Contact
+1-877-825-3327
Email Contact

Trial DescriptionMulti-Institution Registry of SRS/SBRT Procedures

Disease/ConditionNeoplasms
Arteriovenous Malformation of Central Nervous System
Trigeminal Neuralgia

Principal InvestigatorMadhur Garg

Contact
Email Contact

Trial DescriptionMulti-Institution Registry of SRS/SBRT Procedures

Disease/ConditionNeoplasms
Arteriovenous Malformation of Central Nervous System
Trigeminal Neuralgia

Principal InvestigatorMadhur Garg

Contact
Email Contact

Trial DescriptionNational Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) - A Collaborative Initiative to Improve Care of Children With Complex Congenital Heart Disease

Disease/ConditionHypoplastic Left Heart Syndrome (HLHS)

Principal InvestigatorNicole Sutton

Contact
Email Contact

Trial DescriptionNational Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) - A Collaborative Initiative to Improve Care of Children With Complex Congenital Heart Disease

Disease/ConditionHypoplastic Left Heart Syndrome (HLHS)

Principal InvestigatorNicole Sutton

Contact
Email Contact

Trial DescriptionNatural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections

Disease/ConditionMycobacterium Infections

Principal InvestigatorSteven Porcelli

Contact
(301) 443-2163
Email Contact

Trial DescriptionNatural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections

Disease/ConditionMycobacterium Infections

Principal InvestigatorSteven Porcelli

Contact
(301) 443-2163
Email Contact

Trial DescriptionNCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Ensartinib in Patients With Tumors Harboring ALK or ROS1 Genomic Alterations

Disease/ConditionAdvanced Malignant Solid Neoplasm
Malignant Solid Neoplasm
Recurrent Ependymoma
Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Recurrent Hepatoblastoma
Recurrent Langerhans Cell Histiocytosis
Recurrent Malignant Germ Cell Tumor
Recurrent Malignant Glioma
Recurrent Malignant Solid Neoplasm
Recurrent Medulloblastoma
Recurrent Neuroblastoma
Recurrent Non-Hodgkin Lymphoma
Recurrent Osteosarcoma
Recurrent Primary Central Nervous System Neoplasm
Recurrent Rhabdoid Tumor
Recurrent Rhabdomyosarcoma
Recurrent Soft Tissue Sarcoma
Refractory Ependymoma
Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Refractory Hepatoblastoma
Refractory Langerhans Cell Histiocytosis
Refractory Malignant Germ Cell Tumor
Refractory Malignant Glioma
Refractory Malignant Solid Neoplasm
Refractory Medulloblastoma
Refractory Neuroblastoma
Refractory Non-Hodgkin Lymphoma
Refractory Osteosarcoma
Refractory Primary Central Nervous System Neoplasm
Refractory Rhabdoid Tumor
Refractory Rhabdomyosarcoma
Refractory Soft Tissue Sarcoma
Wilms Tumor

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionNCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

Disease/ConditionAdvanced Malignant Solid Neoplasm
Ann Arbor Stage III Non-Hodgkin Lymphoma
Ann Arbor Stage IV Non-Hodgkin Lymphoma
Histiocytic Sarcoma
Juvenile Xanthogranuloma
Langerhans Cell Histiocytosis
Malignant Glioma
Recurrent Childhood Rhabdomyosarcoma
Recurrent Ependymoma
Recurrent Ewing Sarcoma
Recurrent Glioma
Recurrent Hepatoblastoma
Recurrent Langerhans Cell Histiocytosis
Recurrent Malignant Germ Cell Tumor
Recurrent Malignant Solid Neoplasm
Recurrent Medulloblastoma
Recurrent Neuroblastoma
Recurrent Non-Hodgkin Lymphoma
Recurrent Osteosarcoma
Recurrent Peripheral Primitive Neuroectodermal Tumor
Recurrent Primary Central Nervous System Neoplasm
Recurrent Rhabdoid Tumor
Recurrent Soft Tissue Sarcoma
Refractory Ewing Sarcoma
Refractory Glioma
Refractory Hepatoblastoma
Refractory Langerhans Cell Histiocytosis
Refractory Malignant Germ Cell Tumor
Refractory Malignant Solid Neoplasm
Refractory Medulloblastoma
Refractory Neuroblastoma
Refractory Non-Hodgkin Lymphoma
Refractory Osteosarcoma
Refractory Peripheral Primitive Neuroectodermal Tumor
Refractory Primary Central Nervous System Neoplasm
Refractory Rhabdoid Tumor
Refractory Rhabdomyosarcoma
Rhabdoid Tumor
Stage III Osteosarcoma AJCC v7
Stage III Soft Tissue Sarcoma AJCC v7
Stage IV Osteosarcoma AJCC v7
Stage IV Soft Tissue Sarcoma AJCC v7
Stage IVA Osteosarcoma AJCC v7
Stage IVB Osteosarcoma AJCC v7
Wilms Tumor

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionNephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network

Disease/ConditionMinimal Change Disease (MCD)
Membranous Nephropathy
Glomerulosclerosis, Focal Segmental

Principal InvestigatorFrederick Kaskel

Contact
734-615-5021
Email Contact

Trial DescriptionNeuroblastoma Biology Studies

Disease/ConditionGanglioneuroblastoma
Localized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Regional Neuroblastoma
Stage 4 Neuroblastoma
Stage 4S Neuroblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionNeuroblastoma Biology Studies

Disease/ConditionGanglioneuroblastoma
Localized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Regional Neuroblastoma
Stage 4 Neuroblastoma
Stage 4S Neuroblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionNeuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer

Disease/ConditionChildhood Malignant Neoplasm

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionNeuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer

Disease/ConditionChildhood Malignant Neoplasm

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionNMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

Disease/ConditionNeuroblastoma

Principal InvestigatorDaniel Weiser

Contact
7175310003
Email Contact

Trial DescriptionObservational Study of Pediatric Rheumatic Diseases: The CARRA Registry

Disease/ConditionRheumatic Joint Disease

Principal InvestigatorDawn Wahezi

Contact
(919) 419-5032
Email Contact

Trial DescriptionObservational Study of Pediatric Rheumatic Diseases: The CARRA Registry

Disease/ConditionRheumatic Joint Disease

Principal InvestigatorDawn Wahezi

Contact
(919) 419-5032
Email Contact

Trial DescriptionONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study

Disease/ConditionH3 K27M
Glioma

Principal InvestigatorAdilia Hormigo

Contact
1-919-806-1074
Email Contact

Trial DescriptionOptimizing the Patient Experience: Virtual Reality Goggle Utilization for Venipuncture Distraction - Can we Decrease Anxiety and Pain During This Common Procedure?

Disease/ConditionPain, Procedural

Principal InvestigatorCourtney Mcnamara

Contact
540 514 4389
Email Contact

Trial DescriptionPazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754)

Disease/ConditionAlveolar Soft Part Sarcoma
Angiomatoid Fibrous Histiocytoma
Atypical Fibroxanthoma
Clear Cell Sarcoma of Soft Tissue
Epithelioid Malignant Peripheral Nerve Sheath Tumor
Epithelioid Sarcoma
Extraskeletal Myxoid Chondrosarcoma
Extraskeletal Osteosarcoma
Fibrohistiocytic Neoplasm
Fibrosarcoma
Inflammatory Myofibroblastic Tumor
Intimal Sarcoma
Leiomyosarcoma
Liposarcoma
Liver Embryonal Sarcoma
Low Grade Fibromyxoid Sarcoma
Low Grade Myofibroblastic Sarcoma
Malignant Peripheral Nerve Sheath Tumor
Malignant Skin Granular Cell Tumor
Malignant Triton Tumor
Mesenchymal Chondrosarcoma
Myxofibrosarcoma
Myxoid Chondrosarcoma
Myxoinflammatory Fibroblastic Sarcoma
Nerve Sheath Neoplasm
PEComa
Pericytic Neoplasm
Plexiform Fibrohistiocytic Tumor
Sclerosing Epithelioid Fibrosarcoma
Skin Glomus Tumor
Stage IB Soft Tissue Sarcoma AJCC v7
Stage IIB Soft Tissue Sarcoma AJCC v7
Stage III Soft Tissue Sarcoma AJCC v7
Stage IV Soft Tissue Sarcoma AJCC v7
Synovial Sarcoma
Undifferentiated High Grade Pleomorphic Sarcoma of Bone

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionPediatric Hepatic Malignancy International Therapeutic Trial (PHITT)

Disease/ConditionChildhood Hepatocellular Carcinoma
Childhood Malignant Liver Neoplasm
Fibrolamellar Carcinoma
Hepatoblastoma
Hepatocellular Malignant Neoplasm, Not Otherwise Specified

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionPhase 1-2 Trial of Gamunex (intravenous Gammaglobulin) for Sickle Cell Acute Pain

Disease/ConditionSickle Cell Disease
Pain

Principal InvestigatorDeepa Manwani

Contact
718-741-2342
Email Contact

Trial DescriptionPhase 1-2 Trial of Gamunex (intravenous Gammaglobulin) for Sickle Cell Acute Pain

Disease/ConditionSickle Cell Disease
Pain

Principal InvestigatorDeepa Manwani

Contact
718-741-2342
Email Contact

Trial DescriptionPhase 2 Study of Tovorafenib (DAY101) in Relapsed and Refractory Langerhans Cell Histiocytosis

Disease/ConditionRecurrent Langerhans Cell Histiocytosis
Refractory Langerhans Cell Histiocytosis

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionPhase I/II Study of CaspaCIDe® T Cells From an HLA-Partially Matched Family Donor After Negative Selection of TCR αβ+T Cells in Pediatric Patients Affected by Hematological Disorders

Disease/ConditionAcute Lymphoblastic Leukemia
Leukemia, Acute Myeloid (AML), Child
Lymphoma, Non-Hodgkin
Myelodysplastic Syndromes
Primary Immune Deficiency Disorder
Osteopetrosis
Cytopenia
Hemoglobinopathy in Children
Anemia, Aplastic

Principal InvestigatorMichelle Lee

Contact
Email Contact

Principal InvestigatorMichelle Lee

Contact
Email Contact

Trial DescriptionPhase II Study of Nab-Paclitaxel in Combination With Gemcitabine for Treatment of Recurrent/Refractory Sarcoma in Teenagers and Young Adults

Disease/ConditionOsteosarcoma
Ewing Sarcoma
Rhabdomyosarcoma
Soft Tissue Sarcoma

Principal InvestigatorDaniel Weiser

Contact
Email Contact

Trial DescriptionPhase III Multicenter Open-label Randomized Clinical Trial Comparing Everolimus and Low Dose Tacrolimus to Tacrolimus and Mycophenolate Mofetil at 6 mo Post-Transplant to Prevent Long-term Complications After Pediatric Heart Transplantation

Disease/ConditionPediatric Heart Transplantation
Immunosuppression
Chronic Kidney Diseases
Cardiac Allograft Vasculopathy
Heart Transplant Failure and Rejection
Post-transplant Lymphoproliferative Disorder
Heart Transplant Infection

Principal InvestigatorDaphne Hsu

Contact
Email Contact

Trial DescriptionPhase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue

Disease/ConditionLocalized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Recurrent Neuroblastoma
Regional Neuroblastoma
Stage 4 Neuroblastoma
Stage 4S Neuroblastoma

Principal InvestigatorJonathan Gill

Contact
Email Contact

Trial DescriptionPhase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue

Disease/ConditionLocalized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Recurrent Neuroblastoma
Regional Neuroblastoma
Stage 4 Neuroblastoma
Stage 4S Neuroblastoma

Principal InvestigatorJonathan Gill

Contact
Email Contact

Trial DescriptionPhase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 Years

Disease/ConditionAnaplastic Ependymoma
Brain Ependymoma
Cellular Ependymoma
Clear Cell Ependymoma
Ependymoma
Papillary Ependymoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionPhase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 Years

Disease/ConditionAnaplastic Ependymoma
Brain Ependymoma
Cellular Ependymoma
Clear Cell Ependymoma
Ependymoma
Papillary Ependymoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionPhosphate Binder Therapy and Chronic Kidney Disease in Children

Disease/ConditionChronic Kidney Diseases

Principal InvestigatorFrederick Kaskel

Contact
310-7943144
Email Contact

Trial DescriptionPromoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination

Disease/ConditionAsthma Childhood

Principal InvestigatorMarina Reznik

Contact
Email Contact

Trial DescriptionPromoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination

Disease/ConditionAsthma Childhood

Principal InvestigatorMarina Reznik

Contact
Email Contact

Trial DescriptionProspective Cohort Study to Evaluate Immunologic Response Following COVID-19 Vaccination in Children, Adolescents and Young Adults With Cancer

Disease/ConditionCOVID-19 Infection
Hematopoietic and Lymphatic System Neoplasm
Malignant Solid Neoplasm

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionProtocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Disease/ConditionAutologous Stem Cell Transplantation
Allogeneic Stem Cell Transplantation
Solid Tumors
Blood Cancers
CAR-T
Gene Therapy
Non-malignant Disease

Principal InvestigatorMichelle Lee

Contact
763 406 3280
Email Contact

Trial DescriptionProtocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Disease/ConditionAutologous Stem Cell Transplantation
Allogeneic Stem Cell Transplantation
Solid Tumors
Blood Cancers
CAR-T
Gene Therapy
Non-malignant Disease

Principal InvestigatorMichelle Lee

Contact
763 406 3280
Email Contact

Trial DescriptionRandomized Phase 3 Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008) to Multiagent Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Disease/ConditionMetastatic Ewing Sarcoma
Metastatic Malignant Neoplasm in the Bone
Metastatic Malignant Neoplasm in the Bone Marrow
Metastatic Malignant Neoplasm in the Lung
Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone
Peripheral Primitive Neuroectodermal Tumor of Soft Tissues

Principal InvestigatorAlice Lee

Contact
Email Contact

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionRandomized Study of Intravenous Calaspargase Pegol (SC-PEG Asparaginase) and Intravenous Oncaspar in Children and Adolescents With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Disease/ConditionAcute Lymphoblastic Leukemia
Lymphoblastic Lymphoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Disease/ConditionAcute Lymphoblastic Leukemia
Lymphoblastic Lymphoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionRenal Tumors Classification, Biology, and Banking Study - PRIMARY OBJECTIVES: I. Classify patients with renal tumors by histological categorization, surgico-pathological stage, presence of metastases, age at diagnosis, tumor weight, and loss of heterozygosity for chromosomes 1p and 16q, to define eligibility for a series of therapeutic studies. (As of Amendment 8, this aim is limited to patients with institutionally classified Stage I to IV focal or diffuse anaplasia identified at initial biopsy or primary nephrectomy OR at delayed nephrectomy/second biopsy.) II. To maintain a biological samples bank to make specimens available to scientists to evaluate additional potential biological prognostic variables and for the conduct of other research by scientists. SECONDARY OBJECTIVES: I. To monitor outcome for those patients who are not eligible for a subsequent therapeutic study. II. To describe whether the pulmonary tumor burden correlates with outcome in Stage IV patients.(Completed as of Amendment 7) III. To describe the sensitivity and specificity of abdominal computed tomography (CT) by comparison with surgical and pathologic findings for identification of local tumor spread beyond the renal capsule to adjacent muscle and organs, lymph node involvement at the renal hilum and in the retroperitoneum, preoperative tumor rupture and metastases to the liver. (Completed as of Amendment 7) IV. To compare the sensitivity and specificity of preoperative abdominal CT and MRI for the identification and differentiation of nephrogenic rests and Wilms tumor in children with multiple renal lesions. (Completed as of Amendment 7) V. To correlate the method of conception (natural versus assisted reproductive technology) with the development of Wilms tumor. (Completed as of Amendment 7) VI. To evaluate the frequency of integrase interactor 1 (INI1) mutations in renal and extrarenal malignant rhabdoid tumor of the kidney and to determine the incidence of germline and inherited versus somatic mutations to facilitate clinical correlations on the companion study AREN0321. (Completed as of Amendment 7) OUTLINE: Tumor tissue, blood, and urine samples are collected for research studies, including immunohistochemistry. CT scans and MRIs are also performed. Loss of heterozygosity analyses (chromosome 1p and 16q) are performed by extraction of DNA. DNA polymorphisms are assayed by polymerase chain reaction using standard methodology. Leftover specimens are archived for future studies. (LOH and INI1 testing discontinued as of April 2014) Patients are followed up periodically for 5 years.

Disease/ConditionAdult Cystic Nephroma
Anaplastic Kidney Wilms Tumor
Angiolipoma
Cellular Congenital Mesoblastic Nephroma
Classic Congenital Mesoblastic Nephroma
Clear Cell Sarcoma of the Kidney
Congenital Mesoblastic Nephroma
Cystic Partially Differentiated Kidney Nephroblastoma
Diffuse Hyperplastic Perilobar Nephroblastomatosis
Extrarenal Rhabdoid Tumor
Kidney Medullary Carcinoma
Kidney Neoplasm
Kidney Oncocytoma
Kidney Wilms Tumor
Metanephric Adenofibroma
Metanephric Adenoma
Metanephric Stromal Tumor
Metanephric Tumor
Mixed Congenital Mesoblastic Nephroma
Ossifying Renal Tumor of Infancy
Papillary Renal Cell Carcinoma
Renal Cell Carcinoma
Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions
Rhabdoid Tumor of the Kidney
Wilms Tumor

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionRisk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)

Disease/ConditionRecurrent B Acute Lymphoblastic Leukemia

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionRisk-Stratified Randomized Phase III Testing of Blinatumomab (NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)

Disease/ConditionRecurrent B Acute Lymphoblastic Leukemia

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionSafety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve

Disease/ConditionAortic Stenosis, Severe

Principal InvestigatorMohamed Azeem Latib

Contact
949-250-2500
Email Contact

Trial DescriptionSickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease

Disease/ConditionSickle Cell Disease

Principal InvestigatorDeepa Manwani

Contact
(216) 368-6447
Email Contact

Trial DescriptionSickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease

Disease/ConditionSickle Cell Disease

Principal InvestigatorDeepa Manwani

Contact
(216) 368-6447
Email Contact

Trial DescriptionSimple Bone Cysts in Kids (SBoCK)

Disease/ConditionBone Cyst

Principal InvestigatorJacob Schulz

Contact
Email Contact

Trial DescriptionSimple Bone Cysts in Kids (SBoCK)

Disease/ConditionBone Cyst

Principal InvestigatorJacob Schulz

Contact
Email Contact

Trial DescriptionSingle-arm, Open-label, Phase 1b/2 Trial of Nivolumab Therapy Following Partially HLA Mismatched (Haploidentical) Bone Marrow Transplant in Children and Young Adults With High Risk, Recurrent or Refractory Sarcomas

Disease/ConditionSarcoma
Solid Tumor, Adult
Solid Tumor, Childhood

Principal InvestigatorDavid Loeb

Contact
410-955-0432
Email Contact

Trial DescriptionStudy for the Prediction of Active Rejection in Organs Using Donor-derived Cell-free DNA Detection

Disease/ConditionTransplant Rejection
Allograft Rejection
Complications

Principal InvestigatorNicole Hayde

Contact
6502499090
Email Contact

Trial DescriptionThe Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

Disease/ConditionAdrenal Gland Pheochromocytoma
Carcinoma In Situ
Central Nervous System Neoplasm
Childhood Immature Teratoma
Childhood Langerhans Cell Histiocytosis
Childhood Mature Teratoma
Congenital Mesoblastic Nephroma
Desmoid Fibromatosis
Ganglioneuroma
Lymphoproliferative Disorder
Malignant Neoplasm
Malignant Solid Neoplasm
Melanocytic Neoplasm
Myeloproliferative Neoplasm
Neoplasm of Uncertain Malignant Potential
Neuroendocrine Neoplasm
Stromal Neoplasm

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionThe Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionThe Tether™ - Vertebral Body Tethering System Post Approval Study

Disease/ConditionScoliosis Idiopathic

Principal InvestigatorJaime Gomez

Contact
1-303-465-8960
Email Contact

Trial DescriptionTransvenous Approach for the Treatment of Cerebral Arteriovenous Malformations (TATAM): A Randomized Controlled Trial and Registry

Disease/ConditionArteriovenous Malformations, Cerebral
Unruptured Brain Arteriovenous Malformation
Ruptured Brain Arteriovenous Malformation

Principal InvestigatorDavid Altschul

Contact
Email Contact

Trial DescriptionTreatment for Patients With Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor

Disease/ConditionAdult Kidney Wilms Tumor
Beckwith-Wiedemann Syndrome
Childhood Kidney Wilms Tumor
Diffuse Hyperplastic Perilobar Nephroblastomatosis
Rhabdoid Tumor of the Kidney
Stage I Kidney Wilms Tumor
Stage II Kidney Wilms Tumor
Stage III Kidney Wilms Tumor
Stage IV Kidney Wilms Tumor
Stage V Kidney Wilms Tumor

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionTreatment for Patients With Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionTreatment of Children With All Stages of Hepatoblastoma With Temsirolimus (NSC#683864) Added to High Risk Stratum Treatment

Disease/ConditionPRETEXT I Hepatoblastoma
PRETEXT II Hepatoblastoma
PRETEXT III Hepatoblastoma
PRETEXT IV Hepatoblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionTreatment of Children With All Stages of Hepatoblastoma With Temsirolimus (NSC#683864) Added to High Risk Stratum Treatment

Disease/ConditionPRETEXT I Hepatoblastoma
PRETEXT II Hepatoblastoma
PRETEXT III Hepatoblastoma
PRETEXT IV Hepatoblastoma

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionTreatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Disease/ConditionAcute Lymphoblastic Leukemia, Pediatric

Principal InvestigatorLisa Gennarini

Contact
Email Contact

Trial DescriptionTreatment of Patients With Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-Lineage Lymphoblastic Lymphoma (B-LLy)

Disease/ConditionAcute Lymphoblastic Leukemia
Adult B Lymphoblastic Lymphoma
Ann Arbor Stage I B Lymphoblastic Lymphoma
Ann Arbor Stage II B Lymphoblastic Lymphoma
Childhood B Acute Lymphoblastic Leukemia
Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Childhood B Lymphoblastic Lymphoma
Down Syndrome
Hypodiploid B Acute Lymphoblastic Leukemia
Philadelphia Chromosome Positive

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionTreatment of Patients With Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-Lineage Lymphoblastic Lymphoma (B-LLy)

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionTrialNet Pathway to Prevention of T1D

Disease/ConditionDiabetes Mellitus, Type 1

Principal InvestigatorLisa Underland

Contact
1-800-425-8361
Email Contact

Trial DescriptionTrifecta-Heart cfDNA-MMDX Study: Comparing the DD-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test

Disease/ConditionHeart Transplant Rejection

Principal InvestigatorSnehal Patel

Contact
1 780 782 9463
Email Contact

Trial DescriptionTumor-Agnostic Precision Immunooncology and Somatic Targeting Rational for You (TAPISTRY) Phase II Platform Trial

Disease/ConditionSolid Tumors

Principal InvestigatorHaiying Cheng

Contact
888-662-6728 (U.S. and Canada)
Email Contact

Trial DescriptionUmbrella Long-Term Follow-Up Protocol

Disease/ConditionHematopoietic Cell Transplantation Recipient
Leukemia
Solid Tumor

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionUmbrella Long-Term Follow-Up Protocol

Disease/ConditionHematopoietic Cell Transplantation Recipient
Leukemia
Solid Tumor

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionUS Selumetinib Registry

Disease/ConditionNeurofibromatosis Type 1
Plexiform Neurofibromas

Principal InvestigatorNagma Dalvi

Contact
1-855-752-2356
Email Contact

Trial DescriptionUtilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma

Disease/ConditionGanglioneuroblastoma
Localized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Neuroblastoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionUtilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma

Disease/ConditionGanglioneuroblastoma
Localized Resectable Neuroblastoma
Localized Unresectable Neuroblastoma
Neuroblastoma

Principal InvestigatorAlice Lee

Contact
Email Contact

Trial DescriptionViral Infection and Respiratory Illness Universal Study[VIRUS]: COVID-19 Registry and Validation of C2D2 (Critical Care Data Dictionary)

Disease/ConditionCoronavirus

Principal InvestigatorJen-Ting Chen

Contact
5072557196
Email Contact

View all Clinical Trials