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Research

The depth and breadth of expertise within the Division of Neurosurgery spans the clinical spectrum of problems affecting children’s brains, spinal cords and nerves.

Our unique team approach to managing challenging neurological problems has improved outcomes, reduced the number of surgeries that children require and allowed patients’ advanced access to innovative treatments.

Innovation is at the heart of all we do. Our division, for instance, was among the first to use cranial vault reconstruction (CVR) to reshape the head and among the first to modify and use CVR techniques for mid-face reconstructions following trauma or tumor resection.

We are currently focused on research to:

Evaluate Hydrocephalus-Linked Headaches Using Magnetic Resonance Elastography

Our division is pioneering new diagnostic options for hydrocephalic children with chronic headaches. By implanting a pressure sensor and conducting ICU-based monitoring, we can assess potential correlations between headaches and intracranial pressure. In collaboration with radiologists, we are also developing a groundbreaking magnetic resonance elastography technique that noninvasively gauges whether brain tissue elasticity decreases due to shunting.

Provide New Treatment Options for Children and Adults with Chronic Disabilities

Focal hypertonicity accompanying conditions such as cerebral palsy, spina bifida and stroke can freeze joints and severely impede normal movement. Injection-based denervation therapies offer only temporary relief or weaken muscles. We are seeing promising initial results using an alternative method of selectively cutting only problematic nerve fibers thereby resolving abnormal spasticity and other forms of hypertonicity while preserving muscle strength and function.

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionClinical characterization of the pre-ictal state in the pediatric population: A caretaker's perspective on seizure prediction IRB# 2013-2455
Disease/ConditionBrain and Neurological
Principal InvestigatorSheryl Haut, MD
Contact Puja Patel
(917) 205-7283
Email Contact
Trial DescriptionInfantile Spasms Multicenter Database IRB# 13-01-027
Disease/ConditionBrain and Neurological
Principal InvestigatorElissa Yozawitz, MD
Contact Elissa Yozawitz, MD
(718) 920-4378
Email Contact
Trial DescriptionMaintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma - Click here for more informationIRB# 10-07-196
Disease/ConditionBrain and Neurological
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionStudy to Evaluate the Long-term Safety and Tolerability of USL261 in Patients With Seizure Clusters - Click here for more informationOCT11-0108B; IRB# 11-10-322
Disease/ConditionBrain and Neurological
Principal InvestigatorAlexis Boro, MD
Contact Elan Shoulders, MPH
(718) 920-2898
Email Contact
Trial DescriptionStudy to Evaluate the Safety and Efficacy of USL261 (Intranasal Midazolam) in Patients With Seizure Clusters (ARTEMIS1) - Click here for more informationIRB# 11-10-127
Disease/ConditionBrain and Neurological
Principal InvestigatorAlexis Boro, MD
Contact Elan Shoulders
(718) 920-2898
Email Contact
Trial DescriptionThe use of Virtual Reality Games to Enhance Therapy for Children with Cerebral Palsy. A pilot Study IRB# 2008-347
Disease/ConditionBrain and Neurological
Principal InvestigatorMaria Valicenti-McDermott, MD
Contact Maria Valicenti-McDermott, MD
(718) 430-8600 Ext 6275
Email Contact
View all Clinical Trials